Paul Hartley

Dr Paul Hartley

  • 01202 961682
  • phartley at bournemouth dot ac dot uk
  • Senior Lecturer in Functional Genetics
  • SciTech
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Biography

2005: PhD from the University of Edinburgh School of Clinical and Surgical Science (Supervisors Dr. Simon Brown & Prof. John Savill)

1995: BSc (Hons) University of Abertay Dundee, Biotechnology (1st class)

2000: Medical Research Council Human Reproductive Unit (Prof. Richard Anderson’s group)

2005: Medical Research Council Human Genetics Unit (Prof. Julia Dorin’s group)

2007: University of Edinburgh Circadian Physiology Group (Prof. Tony Harmar’s group)

2009: Principal Investigator, University of Edinburgh Centre for Cardiovascular Sciences

2013: British Heart Foundation Intermediate Basic Science Fellow

2013: Visiting Scientist Sanford Burnham Medical Research Inst, California (Prof. Rolf Bodmer’s group)

2015: Senior Lecturer (Functional Genetics) Bournemouth University

Research

I’m interested in gene function and the use of non-mammalian animal models to assist our understanding of how genes affect basic cellular processes - especially the processes relevant to ageing and disease in humans.

There’s an ever-increasing wealth of data linking variance in our genes with disease and ageing. However, experimental systems to study these links are often expensive, difficult to establish and ethically challenging. Progress, therefore, can be slow.

Our approach involves the fruit fly (Drosophila), a simple organism that’s been of central importance to genetic research for over a century. By studying the fly’s heart and kidney function we’re gaining important insights into cardiovascular physiology. These insights are helping establish which genetic mutations promote disease and prevent healthy ageing in humans.

Journal Articles

  • Hartley, P., 2016. SPARC-Dependent Cardiomyopathy in Drosophila. Circulation: Cardiovascular Genetics.
  • Ivy, J.R., Drechsler, M., Catterson, J.H., Bodmer, R., Ocorr, K., Paululat, A. and Hartley, P.S., 2015. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLOS ONE, 10 (8).
  • Catterson, J.H., Heck, M.M.S. and Hartley, P.S., 2013. Fermitins, the Orthologs of Mammalian Kindlins, Regulate the Development of a Functional Cardiac Syncytium in Drosophila melanogaster. PLOS ONE, 8 (5).
  • Hartley, P.S., 2013. Mice housed in groups of 4-6 exhibit a diurnal surge in their platelet count. PLATELETS, 24 (5), 412-414.
  • Tracey, C.J., Pan, X., Catterson, J.H., Harmar, A.J., Hussain, M.M. and Hartley, P.S., 2012. Diurnal expression of the thrombopoietin gene is regulated by CLOCK. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10 (4), 662-669.
  • Hartley, P.S., 2012. The diurnal tick-tockery of platelet biology. PLATELETS, 23 (2), 157-160.
  • Catterson, J.H., Knowles-Barley, S., James, K., Heck, M.M.S., Harmar, A.J. and Hartley, P.S., 2010. Dietary Modulation of Drosophila Sleep-Wake Behaviour. PLOS ONE, 5 (8).
  • Hartley, P.S., Sheward, J., Scholefield, E., French, K., Horn, J.M., Holmes, M.C. and Harmar, A.J., 2009. Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes. BRITISH JOURNAL OF HAEMATOLOGY, 146 (2), 185-192.
  • Hartley, P.S., Sheward, W.J., French, K., Horn, J.M., Holmes, M.C. and Harmar, A.J., 2008. Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 6 (7), 1144-1152.
  • Hartley, P.S., Savill, J.S. and Brown, S.B., 2007. Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity. PLATELETS, 18 (2), 103-112.
  • Hartley, P.S., 2007. Platelet senescence and death. CLINICAL LABORATORY, 53 (3-4), 157-166.
  • Hartley, P.S., Savill, J. and Brown, S.B., 2006. The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets. THROMBOSIS AND HAEMOSTASIS, 95 (1), 100-106.
  • da Silva, S.J.M., Bayne, R.A.L., Cambray, N., Hartley, P.S., McNeilly, A.S. and Anderson, R.A., 2004. Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. DEVELOPMENTAL BIOLOGY, 266 (2), 334-345.
  • Hartley, P.S., Bayne, R.A.L., Robinson, L.L.L., Fulton, N. and Anderson, R.A., 2002. Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 87 (7), 3417-3427.
  • Anderson, R.A., Cambray, N., Hartley, P.S. and McNeilly, A.S., 2002. Expression and localization of inhibin alpha, inhibin/activin beta A and beta B and the activin type II and inhibin beta-glycan receptors in the developing human testis. REPRODUCTION, 123 (6), 779-788.
  • Hartley, P.S., Dawson, B., Lindsay, C., McCormick, P. and Wishart, G., 1999. Cryopreservation of houbara semen: A pilot study. Zoo Biology, 18, 147-152.

Conferences

  • Hurcombe, J., Hartley, P. et al., 2017. Podocyte glycogen synthase kinase 3 (GSK3) is an evolutionarily conserved master regulator of glomerular/excretory function controlling podocyte differentiation and cell cycling. In: British Renal Association: UK Kidney Week 2017 19-21 June 2017 Liverpool, UK.
  • Sivakumar, S., Coward, R. and Hartley, P.S., 2017. Insect nephrocytes as a model for human podocyte ageing. In: UK Kidney Week 2017 19-21 June 2017 Liverpool.
  • Hartley, P.S., 2015. SPARC mediates cardiac ageing. In: Weinstein meeting on Cardiovascular Development 2015 28 April-2 May 2015 Boston, USA.
  • Ivy, J.R., Catterson, J.H. and Hartley, P., 2012. Drosophila Bteb2, a Kruppel-like transcription factor, specifies and maintains adult pericardial nephrocytes. In: Physiology 2012 10-14 July 2012 Edinburgh, UK..

PhD Students

  • Kalon Grimes (Establishing the role of mir-137 in the control of human sleep using Drosophila melanogastermodel)

Profile of Teaching UG

  • Practical Skills in Biology (1st Year BSc Biological Sciences)
  • Advanced Skill for Biology (2nd Year BSc Biological Sciences)
  • Biological Research Skills (1st Year BSc Biological Sciences)
  • Genetics (3rd Year BSc Biological Sciences)
  • Cell Biology (1st Year BSc Biological Science)
  • Advanced Cell Biology

Invited Lectures

  • Bristol University
  • University of Osnabruck invited speaker at Dept of Zoology seminar series

Grants

  • Modelling Angiotensin receptor-associated protein (ATRAP) interaction dynamics to define novel targets for treatment of Chronic kidney disease (Kidney Research UK, 01 Jun 2017). Awarded
  • Welcome Trust Seed Award (Wellcome Trust, 11 Jan 2016). Awarded
  • Using the fruit fly Drosophila to understand podocyte biology in diabetic nephropathy - a pilot study (Kidney Research UK, 01 Oct 2015). Awarded
  • Research in the USA on identifying the regulatory pathways controlling human KLF15 using fruit fly genetics (Carnegie Trust, 07 Jan 2014). Awarded
  • Travel Award: Fly heart research at the Sanford Burnham Research Institute, La Jolla, California (SULSA, 15 Jun 2013). Awarded
  • From Flies to Humans: Using Drosophila genetics to study cardiovascular physiology (British Heart Foundation, 01 May 2013). Awarded
  • The role of CLOCK in the control of megakaryocyte development (British Heart Foundation, 01 Oct 2009). Awarded
  • The role of Tuberin and Hamartin (Tsc1 and Tsc2) in the control of Circadian Rhythms (Tuberous Sclerosis Association UK, 01 Apr 2008). Awarded

External Responsibilities

  • Wellcome Trust & University of Edinburgh, Collaborator on Seed Award (2016-2017)

Public Engagement & Outreach Activities

  • Nuffield Research Placements give sixth form students hands-on experience of a professional research environment through a 4 - 6 week placement in their summer holidays. The programme is run by the Nuffield Foundation and works through regional networks to link talented students with organisations undertaking research. We work with over 200 different organisations including universities, commercial companies, voluntary organisations and research institutes. By working with professional researchers, students gain an insight into a wide variety of science, technology, engineering and maths (STEM) careers. By providing a placement, you organisation can give someone a life-changing opportunity that will help transform them into a future scientist.

Networks

  • Reagent network: we provided transgenic flies and antisera to Dr Friedhelm Hildebrandt (the Warren E. Grupe Professor of Pediatrics) at Harvard Medical School's Division of Nephrology, Boston, Massachusetts, USA.
  • Reagent network: we provided Amnionless and dKlf15 antisera to Marta Carrasco Rando and the Centro de Biología Molecular Severo Ochoa, Madrid, Spain.

Conference Presentations

  • UK Kidney Week, Insect nephrocytes as a model for human podocyte ageing, 19 June 2017, Liverpool, UK
  • Weinstein meeting on Cardiovascular Development 2015, SPARC mediates cardiac ageing, 28 April 2015, Boston, USA.
  • Weinstein meeting on Cardiovascular Development 2015, SPARC mediates cardiac ageing, 30 April 2015, Boston, USA.

Qualifications

  • BSc (Hons) in Biotechnology (University of Abertay Dundee, 1999)
  • PhD in Clinical And Surgical Science (University of Edinburgh, 2005)

Memberships

  • Biochem Society, Member (2017-2018),
The data on this page was last updated at 04:08 on June 26, 2017.