Dr Ahmad Ghazal
- aghazal at bournemouth dot ac dot uk
- Post-Doctoral Research Fellow in LCMS
- Christchurch House C124, Talbot Campus, Fern Barrow, Poole, BH12 5BB
Biography
I am an analytical chemist with interest in top down and bottom up proteomic analysis. Obtained my doctoral degree from the University of Aberdeen with research focused on scorpion venom peptides.
Outputs of my work have included the sequence identification of proteins from scorpion venom using Fourier transform - ion cyclotron mass spectrometer (FT-ICR MS) and there antiviral activity against SARS-CoV-2. My work also include establishing a chemoenzymatic strategy that allows late-stage modification of peptides that is useful for many applications.
Research
Currently working on multiple projects, one of which is the quantification of stress hormones in fish scales using liquid chromatography - mass spectrometry (LC-MS).
Other research activity revolved on protein purification through HPLC and sequence identification of scorpion venom peptides, through mass spectrometry and transcriptomic data analysis. In addition, the identified peptides were then synthesized and folded using folding buffers to obtain the same secondary structure as that of the natural peptides, followed by CD-UV analysis.
Journal Articles
- Ghazal, A. et al., 2024. Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity. Peptides, 173, 171139.
- Colombano, A., Dalponte, L., Dall'Angelo, S., Clemente, C., Idress, M., Ghazal, A. and Houssen, W.E., 2023. Chemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides. Angew Chem Int Ed Engl, 62 (16), e202215979.