Modeling Podocyte Biology Using Drosophila Nephrocytes

This data was imported from PubMed:

Authors: Hartley, P.S. and Coward, R.J.

Volume: 2067

Pages: 11-24

DOI: 10.1007/978-1-4939-9841-8_2

Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and cardiovascular morbidity. Due to genetic and functional similarities, the nephrocytes of Drosophila are increasingly used to model the genetic and metabolic basis of human podocyte biology. They have the advantage that they are a much quicker system to study compared to other murine transgenic models. In this chapter we present methods to modulate and study Drosophila nephrocyte function and diaphragm formation.

This data was imported from Scopus:

Authors: Hartley, P.S. and Coward, R.J.

Volume: 2067

Pages: 11-24

DOI: 10.1007/978-1-4939-9841-8_2

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and cardiovascular morbidity. Due to genetic and functional similarities, the nephrocytes of Drosophila are increasingly used to model the genetic and metabolic basis of human podocyte biology. They have the advantage that they are a much quicker system to study compared to other murine transgenic models. In this chapter we present methods to modulate and study Drosophila nephrocyte function and diaphragm formation.

The data on this page was last updated at 05:30 on November 25, 2020.