The threshold for sensing airflow resistance during tidal breathing rises in old age: Implications for elderly patients with obstructive airways diseases

This source preferred by Stephen Allen and Ahmed Khattab

Authors: Allen, S.C., Vassallo, M. and Khattab, A.D.

http://dx.doi.org/10.1093/ageing/afp110

Journal: Age and Ageing

Volume: 38

Pages: 548

ISSN: 0002-0729

DOI: 10.1093/ageing/afp110

Objective: to determine whether the ability of elderly subjects to detect a rise in airflow resistance is attenuated in old age, and to measure the magnitude and variability of such a change.

Methods: we studied 124 healthy adults aged 20–86 years. Progressive external airflow resistance loading was used to measure the inspiratory and expiratory load detection thresholds (LDTs) during tidal breathing at rest.

Results: the mean inspiratory LDT rose from 4.00 (3.06 SD) kPa.s/L in the 20–39 age group to 6.51 (6.20) in the 40–64 age group (NS) and 29.10 (13.58) in the 65 + age group (P < 0.00001). The inspiratory LDT was significantly correlated with age, mainly due to the higher thresholds in people over the age of 65 (r = 0.7860, P < 0.00001), but did not correlate with age-corrected forced vital capacity or respiratory rate. Expiratory LDT values and correlations were very similar. Day-to-day variability in LDTs tended to be higher in older subjects.

Conclusion: the threshold for detecting external resistive loads during tidal breathing rises in old age. This appears to be a consequence of ageing processes rather than pathology, and might be a manifestation of a fall in proprioceptive acuity in elderly people. This finding has clinical implications for the self-management of asthma in old age. There is a need to conduct a similar study in patients with airways disease.

This data was imported from PubMed:

Authors: Allen, S.C., Vassallo, M. and Khattab, A.

Journal: Age Ageing

Volume: 38

Issue: 5

Pages: 548-552

eISSN: 1468-2834

DOI: 10.1093/ageing/afp110

OBJECTIVE: to determine whether the ability of elderly subjects to detect a rise in airflow resistance is attenuated in old age, and to measure the magnitude and variability of such a change. METHODS: we studied 124 healthy adults aged 20-86 years. Progressive external airflow resistance loading was used to measure the inspiratory and expiratory load detection thresholds (LDTs) during tidal breathing at rest. RESULTS: the mean inspiratory LDT rose from 4.00 (3.06 SD) kPa.s/L in the 20-39 age group to 6.51 (6.20) in the 40-64 age group (NS) and 29.10 (13.58) in the 65 + age group (P < 0.00001). The inspiratory LDT was significantly correlated with age, mainly due to the higher thresholds in people over the age of 65 (r = 0.7860, P < 0.00001), but did not correlate with age-corrected forced vital capacity or respiratory rate. Expiratory LDT values and correlations were very similar. Day-to-day variability in LDTs tended to be higher in older subjects. CONCLUSION: the threshold for detecting external resistive loads during tidal breathing rises in old age. This appears to be a consequence of ageing processes rather than pathology, and might be a manifestation of a fall in proprioceptive acuity in elderly people. This finding has clinical implications for the self-management of asthma in old age. There is a need to conduct a similar study in patients with airways disease.

This data was imported from Scopus:

Authors: Allen, S.C., Vassallo, M. and Khattab, A.

Journal: Age and Ageing

Volume: 38

Issue: 5

Pages: 548-552

eISSN: 1468-2834

ISSN: 0002-0729

DOI: 10.1093/ageing/afp110

Objective: to determine whether the ability of elderly subjects to detect a rise in airflow resistance is attenuated in old age, and to measure the magnitude and variability of such a change. Methods: we studied 124 healthy adults aged 20-86 years. Progressive external airflow resistance loading was used to measure the inspiratory and expiratory load detection thresholds (LDTs) during tidal breathing at rest. Results: the mean inspiratory LDT rose from 4.00 (3.06 SD) kPa.s/L in the 20-39 age group to 6.51 (6.20) in the 40-64 age group (NS) and 29.10 (13.58) in the 65 + age group (P < 0.00001). The inspiratory LDT was significantly correlated with age, mainly due to the higher thresholds in people over the age of 65 (r = 0.7860, P < 0.00001), but did not correlate with age-corrected forced vital capacity or respiratory rate. Expiratory LDT values and correlations were very similar. Day-to-day variability in LDTs tended to be higher in older subjects. Conclusion: the threshold for detecting external resistive loads during tidal breathing rises in old age. This appears to be a consequence of ageing processes rather than pathology, and might be a manifestation of a fall in proprioceptive acuity in elderly people. This finding has clinical implications for the self-management of asthma in old age. There is a need to conduct a similar study in patients with airways disease. © The Author 2009. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.

This data was imported from Web of Science (Lite):

Authors: Allen, S.C., Vassallo, M. and Khattab, A.

Journal: AGE AND AGEING

Volume: 38

Issue: 5

Pages: 548-552

eISSN: 1468-2834

ISSN: 0002-0729

DOI: 10.1093/ageing/afp110

This data was imported from Europe PubMed Central:

Authors: Allen, S.C., Vassallo, M. and Khattab, A.

Journal: Age and ageing

Volume: 38

Issue: 5

Pages: 548-552

eISSN: 1468-2834

ISSN: 0002-0729

OBJECTIVE: to determine whether the ability of elderly subjects to detect a rise in airflow resistance is attenuated in old age, and to measure the magnitude and variability of such a change. METHODS: we studied 124 healthy adults aged 20-86 years. Progressive external airflow resistance loading was used to measure the inspiratory and expiratory load detection thresholds (LDTs) during tidal breathing at rest. RESULTS: the mean inspiratory LDT rose from 4.00 (3.06 SD) kPa.s/L in the 20-39 age group to 6.51 (6.20) in the 40-64 age group (NS) and 29.10 (13.58) in the 65 + age group (P < 0.00001). The inspiratory LDT was significantly correlated with age, mainly due to the higher thresholds in people over the age of 65 (r = 0.7860, P < 0.00001), but did not correlate with age-corrected forced vital capacity or respiratory rate. Expiratory LDT values and correlations were very similar. Day-to-day variability in LDTs tended to be higher in older subjects. CONCLUSION: the threshold for detecting external resistive loads during tidal breathing rises in old age. This appears to be a consequence of ageing processes rather than pathology, and might be a manifestation of a fall in proprioceptive acuity in elderly people. This finding has clinical implications for the self-management of asthma in old age. There is a need to conduct a similar study in patients with airways disease.

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