No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial

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This data was imported from PubMed:

Authors: Rogers, P.J., Appleton, K.M., Kessler, D., Peters, T.J., Gunnell, D., Hayward, R.C., Heatherley, S.V., Christian, L.M., McNaughton, S.A. and Ness, A.R.

Journal: Br J Nutr

Volume: 99

Issue: 2

Pages: 421-431

ISSN: 0007-1145

DOI: 10.1017/S0007114507801097

Low dietary intakes of the n-3 long-chain PUFA (LCPUFA) EPA and DHA are thought to be associated with increased risk for a variety of adverse outcomes, including some psychiatric disorders. Evidence from observational and intervention studies for a role of n-3 LCPUFA in depression is mixed, with some support for a benefit of EPA and/or DHA in major depressive illness. The present study was a double-blind randomised controlled trial that evaluated the effects of EPA+DHA supplementation (1.5 g/d) on mood and cognitive function in mild to moderately depressed individuals. Of 218 participants who entered the trial, 190 completed the planned 12 weeks intervention. Compliance, confirmed by plasma fatty acid concentrations, was good, but there was no evidence of a difference between supplemented and placebo groups in the primary outcome - namely, the depression subscale of the Depression Anxiety and Stress Scales at 12 weeks. Mean depression score was 8.4 for the EPA+DHA group and 9.6 for the placebo group, with an adjusted difference of - 1.0 (95 % CI - 2.8, 0.8; P = 0.27). Other measures of mood, mental health and cognitive function, including Beck Depression Inventory score and attentional bias toward threat words, were similarly little affected by the intervention. In conclusion, substantially increasing EPA+DHA intake for 3 months was found not to have beneficial or harmful effects on mood in mild to moderate depression. Adding the present result to a meta-analysis of previous relevant randomised controlled trial results confirmed an overall negligible benefit of n-3 LCPUFA supplementation for depressed mood.

This data was imported from Scopus:

Authors: Rogers, P.J., Appleton, K.M., Kessler, D., Peters, T.J., Gunnell, D., Hayward, R.C., Heatherley, S.V., Christian, L.M., Mcnaughton, S.A. and Ness, A.R.

Journal: British Journal of Nutrition

Volume: 99

Issue: 2

Pages: 421-431

eISSN: 1475-2662

ISSN: 0007-1145

DOI: 10.1017/S0007114507801097

Low dietary intakes of the n-3 long-chain PUFA (LCPUFA) EPA and DHA are thought to be associated with increased risk for a variety of adverse outcomes, including some psychiatric disorders. Evidence from observational and intervention studies for a role of n-3 LCPUFA in depression is mixed, with some support for a benefit of EPA and/or DHA in major depressive illness. The present study was a double-blind randomised controlled trial that evaluated the effects of EPA+DHA supplementation (1.5 g/d) on mood and cognitive function in mild to moderately depressed individuals. Of 218 participants who entered the trial, 190 completed the planned 12 weeks intervention. Compliance, confirmed by plasma fatty acid concentrations, was good, but there was no evidence of a difference between supplemented and placebo groups in the primary outcome - namely, the depression subscale of the Depression Anxiety and Stress Scales at 12 weeks. Mean depression score was 8.4 for the EPA+DHA group and 9.6 for the placebo group, with an adjusted difference of -1.0 (95 % CI -0.8; P=0.27). Other measures of mood, mental health and cognitive function, including Beck Depression Inventory score and attentional bias toward threat words, were similarly little affected by the intervention. In conclusion, substantially increasing EPA+DHA intake for 3 months was found not to have beneficial or harmful effects on mood in mild to moderate depression. Adding the present result to a meta-analysis of previous relevant randomised controlled trial results confirmed an overall negligible benefit of n-3 LCPUFA supplementation for depressed mood. © 2007 The Authors.

This data was imported from Web of Science (Lite):

Authors: Rogers, P.J., Appleton, K.M., Kessler, D., Peters, T.J., Gunnell, D., Hayward, R.C., Heatherley, S.V., Christian, L.M., McNaughton, S.A. and Ness, A.R.

Journal: BRITISH JOURNAL OF NUTRITION

Volume: 99

Issue: 2

Pages: 421-431

ISSN: 0007-1145

DOI: 10.1017/S0007114507801097

This data was imported from Europe PubMed Central:

Authors: Rogers, P.J., Appleton, K.M., Kessler, D., Peters, T.J., Gunnell, D., Hayward, R.C., Heatherley, S.V., Christian, L.M., McNaughton, S.A. and Ness, A.R.

Journal: The British journal of nutrition

Volume: 99

Issue: 2

Pages: 421-431

eISSN: 1475-2662

ISSN: 0007-1145

Low dietary intakes of the n-3 long-chain PUFA (LCPUFA) EPA and DHA are thought to be associated with increased risk for a variety of adverse outcomes, including some psychiatric disorders. Evidence from observational and intervention studies for a role of n-3 LCPUFA in depression is mixed, with some support for a benefit of EPA and/or DHA in major depressive illness. The present study was a double-blind randomised controlled trial that evaluated the effects of EPA+DHA supplementation (1.5 g/d) on mood and cognitive function in mild to moderately depressed individuals. Of 218 participants who entered the trial, 190 completed the planned 12 weeks intervention. Compliance, confirmed by plasma fatty acid concentrations, was good, but there was no evidence of a difference between supplemented and placebo groups in the primary outcome - namely, the depression subscale of the Depression Anxiety and Stress Scales at 12 weeks. Mean depression score was 8.4 for the EPA+DHA group and 9.6 for the placebo group, with an adjusted difference of - 1.0 (95 % CI - 2.8, 0.8; P = 0.27). Other measures of mood, mental health and cognitive function, including Beck Depression Inventory score and attentional bias toward threat words, were similarly little affected by the intervention. In conclusion, substantially increasing EPA+DHA intake for 3 months was found not to have beneficial or harmful effects on mood in mild to moderate depression. Adding the present result to a meta-analysis of previous relevant randomised controlled trial results confirmed an overall negligible benefit of n-3 LCPUFA supplementation for depressed mood.

The data on this page was last updated at 04:57 on May 21, 2019.