Review and meta-analysis of the short-term effects of a vegetable oil emulsion on food intake

This data was imported from PubMed:

Authors: Appleton, K.M., Smit, H.J. and Rogers, P.J.

Journal: Obes Rev

Volume: 12

Issue: 7

Pages: e560-e572

eISSN: 1467-789X

DOI: 10.1111/j.1467-789X.2011.00861.x

Several short-term studies have investigated the effects of a vegetable oil emulsion on subsequent food intake, although findings have been inconsistent. This work aimed to review all studies, and investigate differences in study outcomes based on methodology. All known studies were identified. Data were abstracted from published studies (n = 7). Details of unpublished studies were gained from investigators/sponsors (n = 5), or were unavailable for reasons of confidentiality (n = 4). Available data were combined using meta-analyses. A combined appetite suppressant effect of the emulsion compared with control was found for test meal intake at approximately 4, 12 and 36 h post-treatment: smallest combined mean difference (random effects model) = 0.53 MJ (95% confidence interval 0.20, 0.86), P < 0.01. However, considerable heterogeneity (variability) between study results was also found (smallest I(2) = 94%, P < 0.01), questioning the predictive validity of the above findings. Meta-regression suggested this heterogeneity to be related to differences in the processed nature of the product, treatment dose and in particular year of study (smallest B = 0.54, 95% confidence interval 0.06, 1.03, P = 0.04), although again heterogeneity was found. The only consistent finding was a lack of effect on food intake 4 h post-preload in studies conducted after 2003. These results suggest a small but inconsistent appetite suppressant effect of the vegetable oil emulsion. However, due to the large heterogeneity, no definitive conclusions can be drawn.

This source preferred by Katherine Appleton

This data was imported from Scopus:

Authors: Appleton, K.M., Smit, H.J. and Rogers, P.J.

Journal: Obesity Reviews

Volume: 12

Issue: 7

eISSN: 1467-789X

ISSN: 1467-7881

DOI: 10.1111/j.1467-789X.2011.00861.x

Several short-term studies have investigated the effects of a vegetable oil emulsion on subsequent food intake, although findings have been inconsistent. This work aimed to review all studies, and investigate differences in study outcomes based on methodology. All known studies were identified. Data were abstracted from published studies (n=7). Details of unpublished studies were gained from investigators/sponsors (n=5), or were unavailable for reasons of confidentiality (n=4). Available data were combined using meta-analyses. A combined appetite suppressant effect of the emulsion compared with control was found for test meal intake at approximately 4, 12 and 36h post-treatment: smallest combined mean difference (random effects model)=0.53MJ (95% confidence interval 0.20, 0.86), P<0.01. However, considerable heterogeneity (variability) between study results was also found (smallest I2=94%, P<0.01), questioning the predictive validity of the above findings. Meta-regression suggested this heterogeneity to be related to differences in the processed nature of the product, treatment dose and in particular year of study (smallest B=0.54, 95% confidence interval 0.06, 1.03, P=0.04), although again heterogeneity was found. The only consistent finding was a lack of effect on food intake 4h post-preload in studies conducted after 2003. These results suggest a small but inconsistent appetite suppressant effect of the vegetable oil emulsion. However, due to the large heterogeneity, no definitive conclusions can be drawn. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.

This data was imported from Web of Science (Lite):

Authors: Appleton, K.M., Smit, H.J. and Rogers, P.J.

Journal: OBESITY REVIEWS

Volume: 12

Issue: 7

Pages: E560-E572

ISSN: 1467-7881

DOI: 10.1111/j.1467-789X.2011.00861.x

This data was imported from Europe PubMed Central:

Authors: Appleton, K.M., Smit, H.J. and Rogers, P.J.

Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity

Volume: 12

Issue: 7

Pages: e560-e572

eISSN: 1467-789X

ISSN: 1467-7881

Several short-term studies have investigated the effects of a vegetable oil emulsion on subsequent food intake, although findings have been inconsistent. This work aimed to review all studies, and investigate differences in study outcomes based on methodology. All known studies were identified. Data were abstracted from published studies (n = 7). Details of unpublished studies were gained from investigators/sponsors (n = 5), or were unavailable for reasons of confidentiality (n = 4). Available data were combined using meta-analyses. A combined appetite suppressant effect of the emulsion compared with control was found for test meal intake at approximately 4, 12 and 36 h post-treatment: smallest combined mean difference (random effects model) = 0.53 MJ (95% confidence interval 0.20, 0.86), P < 0.01. However, considerable heterogeneity (variability) between study results was also found (smallest I(2) = 94%, P < 0.01), questioning the predictive validity of the above findings. Meta-regression suggested this heterogeneity to be related to differences in the processed nature of the product, treatment dose and in particular year of study (smallest B = 0.54, 95% confidence interval 0.06, 1.03, P = 0.04), although again heterogeneity was found. The only consistent finding was a lack of effect on food intake 4 h post-preload in studies conducted after 2003. These results suggest a small but inconsistent appetite suppressant effect of the vegetable oil emulsion. However, due to the large heterogeneity, no definitive conclusions can be drawn.

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