Depressed mood and n-3 polyunsaturated fatty acid intake from fish: non-linear or confounded association?

This data was imported from PubMed:

Authors: Appleton, K.M., Peters, T.J., Hayward, R.C., Heatherley, S.V., McNaughton, S.A., Rogers, P.J., Gunnell, D., Ness, A.R. and Kessler, D.

Journal: Soc Psychiatry Psychiatr Epidemiol

Volume: 42

Issue: 2

Pages: 100-104

ISSN: 0933-7954

DOI: 10.1007/s00127-006-0142-3

There is increasing evidence of an association between low dietary intake of essential n-3 long chain polyunsaturated fatty acids (n-3 EFAs) and depressed mood. This study aimed to evaluate this association in a large population-based sample of UK individuals. N-3 EFA intake (intake from fish alone, and from all sources (fish and supplements)), depressed mood (assessed using the short-form Depression, Anxiety and Stress Scales) and demographic variables (sex, age, Index of Multiple Deprivation (IMD) based on postal code, and date of questionnaire completion) were obtained simultaneously by self-report questionnaire (N = 2982). Using polynomial regression, a non-linear relationship between depressed mood and n-3 EFA intake from fish was found, with the incremental decrease in depressed mood diminishing as n-3 EFA intake increased. However, this relationship was attenuated by adjustment for age and IMD. No relationship between depression and n-3 EFA intake from all sources was found. These findings suggest that higher levels of n-3 EFA intake from fish are associated with lower levels of depressed mood, but the association disappears after adjustment for age and social deprivation, and after inclusion of n-3 EFA intake from supplements. This study does have a number of limitations, but the findings available suggest that the apparent associations between depressed mood and n-3 EFA intake from fish may simply reflect a wider association between depressed mood and lifestyle.

This source preferred by Katherine Appleton

This data was imported from Scopus:

Authors: Appleton, K.M., Peters, T.J., Hayward, R.C., Heatherley, S.V., McNaughton, S.A., Rogers, P.J., Gunnell, D., Ness, A.R. and Kessler, D.

Journal: Social Psychiatry and Psychiatric Epidemiology

Volume: 42

Issue: 2

Pages: 100-104

ISSN: 0933-7954

DOI: 10.1007/s00127-006-0142-3

There is increasing evidence of an association between low dietary intake of essential n-3 long chain polyunsaturated fatty acids (n-3 EFAs) and depressed mood. This study aimed to evaluate this association in a large population-based sample of UK individuals. N-3 EFA intake (intake from fish alone, and from all sources (fish and supplements)), depressed mood (assessed using the short-form Depression, Anxiety and Stress Scales) and demographic variables (sex, age, Index of Multiple Deprivation (IMD) based on postal code, and date of questionnaire completion) were obtained simultaneously by self-report questionnaire (N = 2982). Using polynomial regression, a non-linear relationship between depressed mood and n-3 EFA intake from fish was found, with the incremental decrease in depressed mood diminishing as n-3 EFA intake increased. However, this relationship was attenuated by adjustment for age and IMD. No relationship between depression and n-3 EFA intake from all sources was found. These findings suggest that higher levels of n-3 EFA intake from fish are associated with lower levels of depressed mood, but the association disappears after adjustment for age and social deprivation, and after inclusion of n-3 EFA intake from supplements. This study does have a number of limitations, but the findings available suggest that the apparent associations between depressed mood and n-3 EFA intake from fish may simply reflect a wider association between depressed mood and lifestyle. © Steinkopff Verlag Darmstadt 2006.

This data was imported from Web of Science (Lite):

Authors: Appleton, K.M., Peters, T.J., Hayward, R.C., Heatherley, S.V., McNaughton, S.A., Rogers, P.J., Gunnell, D., Ness, A.R. and Kessler, D.

Journal: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Volume: 42

Issue: 2

Pages: 100-104

ISSN: 0933-7954

DOI: 10.1007/s00127-006-0142-3

This data was imported from Europe PubMed Central:

Authors: Appleton, K.M., Peters, T.J., Hayward, R.C., Heatherley, S.V., McNaughton, S.A., Rogers, P.J., Gunnell, D., Ness, A.R. and Kessler, D.

Journal: Social psychiatry and psychiatric epidemiology

Volume: 42

Issue: 2

Pages: 100-104

eISSN: 1433-9285

ISSN: 0933-7954

There is increasing evidence of an association between low dietary intake of essential n-3 long chain polyunsaturated fatty acids (n-3 EFAs) and depressed mood. This study aimed to evaluate this association in a large population-based sample of UK individuals. N-3 EFA intake (intake from fish alone, and from all sources (fish and supplements)), depressed mood (assessed using the short-form Depression, Anxiety and Stress Scales) and demographic variables (sex, age, Index of Multiple Deprivation (IMD) based on postal code, and date of questionnaire completion) were obtained simultaneously by self-report questionnaire (N = 2982). Using polynomial regression, a non-linear relationship between depressed mood and n-3 EFA intake from fish was found, with the incremental decrease in depressed mood diminishing as n-3 EFA intake increased. However, this relationship was attenuated by adjustment for age and IMD. No relationship between depression and n-3 EFA intake from all sources was found. These findings suggest that higher levels of n-3 EFA intake from fish are associated with lower levels of depressed mood, but the association disappears after adjustment for age and social deprivation, and after inclusion of n-3 EFA intake from supplements. This study does have a number of limitations, but the findings available suggest that the apparent associations between depressed mood and n-3 EFA intake from fish may simply reflect a wider association between depressed mood and lifestyle.

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