Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats

This source preferred by Katherine Appleton

This data was imported from PubMed:

Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.

http://eprints.bournemouth.ac.uk/21648/

Journal: Prostaglandins Leukot Essent Fatty Acids

Volume: 95

Pages: 11-18

eISSN: 1532-2823

DOI: 10.1016/j.plefa.2014.11.010

n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.

This data was imported from Scopus:

Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.

http://eprints.bournemouth.ac.uk/21648/

Journal: Prostaglandins Leukotrienes and Essential Fatty Acids

Volume: 95

Pages: 11-18

eISSN: 1532-2823

ISSN: 0952-3278

DOI: 10.1016/j.plefa.2014.11.010

© 2014 The Authors. n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.

This data was imported from Web of Science (Lite):

Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.

http://eprints.bournemouth.ac.uk/21648/

Journal: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Volume: 95

Pages: 11-18

eISSN: 1532-2823

ISSN: 0952-3278

DOI: 10.1016/j.plefa.2014.11.010

This data was imported from Europe PubMed Central:

Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.

http://eprints.bournemouth.ac.uk/21648/

Journal: Prostaglandins, leukotrienes, and essential fatty acids

Volume: 95

Pages: 11-18

eISSN: 1532-2823

ISSN: 0952-3278

n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.

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