Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: A pilot study

Authors: Dean, P.J.A., Otaduy, M.C.G., Harris, L.M., McNamara, A., Seiss, E. and Sterr, A.

Journal: NeuroReport

Volume: 24

Issue: 12

Pages: 677-681

eISSN: 1473-558X

ISSN: 0959-4965

DOI: 10.1097/WNR.0b013e3283637aa4

Abstract:

This pilot study explores the metabolic changes associated with persistent postconcussion syndrome (PCS) after mild traumatic brain injury (mTBI; >12 months after injury) using magnetic resonance spectroscopy. We hypothesized that those mTBI participants with PCS will have larger metabolic differences than those without. Data were collected from mTBI participants with PCS, mTBI participants without PCS and non-head-injured participants (all groups: n=8). Magnetic resonance spectroscopy metabolite profiles within the dorsolateral prefrontal cortex showed a reduced creatine/choline ratio in mTBI patients compared with control participants. This data provides initial evidence for residual metabolic changes in chronic mTBI patients, but there was no conclusive relationship between these metabolic changes and PCS symptom report. Creatine is involved in maintaining energy levels in cells with high or fluctuating energy demand, suggesting that there may be some residual energy impairment in chronic mTBI. © 2013 Wolters Kluwer Health Lippincott Williams & Wilkins.

Source: Scopus

Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study.

Authors: Dean, P.J.A., Otaduy, M.C.G., Harris, L.M., McNamara, A., Seiss, E. and Sterr, A.

Journal: Neuroreport

Volume: 24

Issue: 12

Pages: 677-681

eISSN: 1473-558X

DOI: 10.1097/WNR.0b013e3283637aa4

Abstract:

This pilot study explores the metabolic changes associated with persistent postconcussion syndrome (PCS) after mild traumatic brain injury (mTBI; >12 months after injury) using magnetic resonance spectroscopy. We hypothesized that those mTBI participants with PCS will have larger metabolic differences than those without. Data were collected from mTBI participants with PCS, mTBI participants without PCS and non-head-injured participants (all groups: n=8). Magnetic resonance spectroscopy metabolite profiles within the dorsolateral prefrontal cortex showed a reduced creatine/choline ratio in mTBI patients compared with control participants. This data provides initial evidence for residual metabolic changes in chronic mTBI patients, but there was no conclusive relationship between these metabolic changes and PCS symptom report. Creatine is involved in maintaining energy levels in cells with high or fluctuating energy demand, suggesting that there may be some residual energy impairment in chronic mTBI.

Source: PubMed

Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study

Authors: Dean, P.J.A., Otaduy, M.C.G., Harris, L.M., McNamara, A., Seiss, E. and Sterr, A.

Journal: NEUROREPORT

Volume: 24

Issue: 12

Pages: 677-681

eISSN: 1473-558X

ISSN: 0959-4965

DOI: 10.1097/WNR.0b013e3283637aa4

Source: Web of Science (Lite)

Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study.

Authors: Dean, P.J.A., Otaduy, M.C.G., Harris, L.M., McNamara, A., Seiss, E. and Sterr, A.

Journal: Neuroreport

Volume: 24

Issue: 12

Pages: 677-681

eISSN: 1473-558X

ISSN: 0959-4965

DOI: 10.1097/wnr.0b013e3283637aa4

Abstract:

This pilot study explores the metabolic changes associated with persistent postconcussion syndrome (PCS) after mild traumatic brain injury (mTBI; >12 months after injury) using magnetic resonance spectroscopy. We hypothesized that those mTBI participants with PCS will have larger metabolic differences than those without. Data were collected from mTBI participants with PCS, mTBI participants without PCS and non-head-injured participants (all groups: n=8). Magnetic resonance spectroscopy metabolite profiles within the dorsolateral prefrontal cortex showed a reduced creatine/choline ratio in mTBI patients compared with control participants. This data provides initial evidence for residual metabolic changes in chronic mTBI patients, but there was no conclusive relationship between these metabolic changes and PCS symptom report. Creatine is involved in maintaining energy levels in cells with high or fluctuating energy demand, suggesting that there may be some residual energy impairment in chronic mTBI.

Source: Europe PubMed Central

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