Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men
Authors: Ahrén, B., Mari, A., Fyfe, C.L., Tsofliou, F., Sneddon, A.A., Wahle, K.W., Winzell, M.S., Pacini, G. and Williams, L.M.
Journal: European Journal of Clinical Nutrition
Volume: 63
Issue: 6
Pages: 778-786
eISSN: 1476-5640
ISSN: 0954-3007
DOI: 10.1038/ejcn.2008.45
Abstract:Background/Objectives: Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old, lean and obese subjects was tested. Subjects/Methods: CLA (3 g daily) plus n-3 LC-PUFA (3 g daily) or control oil (6g daily) was given to lean (n = 12; BMI 20-26 kg/m2) or obese (n = 10; BMI 29-35 kg/m2) young (20-37 years old) or lean (n = 16) or obese (n = 11) older men (50-65 years) for 12 weeks. The study had a double-blind, placebo-controlled randomized crossover design, and primary end points were insulin secretion and sensitivity during a standardized meal test, evaluated by modeling glucose, insulin and C-peptide data. Results: The combination was well tolerated. There was no significant difference in fasting levels of glucose, insulin or C-peptide after CLA/n-3 LC-PUFA treatment compared with control oil. Neither insulin secretion nor estimated sensitivity was affected by CLA/n-3 LC-PUFA in lean or obese young subjects or in older lean subjects. However, in older obese subjects, estimated insulin sensitivity was reduced with CLA/n-3 LC-PUFA compared with control (P = 0.024). Conclusions: The resultsdo not support beneficial effects of CLA/n-3 LC-PUFA for β-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced.
Source: Scopus
Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.
Authors: Ahrén, B., Mari, A., Fyfe, C.L., Tsofliou, F., Sneddon, A.A., Wahle, K.W., Winzell, M.S., Pacini, G. and Williams, L.M.
Journal: Eur J Clin Nutr
Volume: 63
Issue: 6
Pages: 778-786
eISSN: 1476-5640
DOI: 10.1038/ejcn.2008.45
Abstract:BACKGROUND/OBJECTIVES: Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old, lean and obese subjects was tested. SUBJECTS/METHODS: CLA (3 g daily) plus n-3 LC-PUFA (3 g daily) or control oil (6 g daily) was given to lean (n=12; BMI 20-26 kg/m(2)) or obese (n=10; BMI 29-35 kg/m(2)) young (20-37 years old) or lean (n=16) or obese (n=11) older men (50-65 years) for 12 weeks. The study had a double-blind, placebo-controlled randomized crossover design, and primary end points were insulin secretion and sensitivity during a standardized meal test, evaluated by modeling glucose, insulin and C-peptide data. RESULTS: The combination was well tolerated. There was no significant difference in fasting levels of glucose, insulin or C-peptide after CLA/n-3 LC-PUFA treatment compared with control oil. Neither insulin secretion nor estimated sensitivity was affected by CLA/n-3 LC-PUFA in lean or obese young subjects or in older lean subjects. However, in older obese subjects, estimated insulin sensitivity was reduced with CLA/n-3 LC-PUFA compared with control (P=0.024). CONCLUSIONS: The results do not support beneficial effects of CLA/n-3 LC-PUFA for beta-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced.
Source: PubMed
Preferred by: Fotini Tsofliou
Effects of conjugated linoleic acid plus <i>n</i>-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men
Authors: Ahren, B., Mari, A., Fyfe, C.L., Tsofliou, F., Sneddon, A.A., Wahle, K.W., Winzell, M.S., Pacini, G. and Williams, L.M.
Journal: EUROPEAN JOURNAL OF CLINICAL NUTRITION
Volume: 63
Issue: 6
Pages: 778-786
eISSN: 1476-5640
ISSN: 0954-3007
DOI: 10.1038/ejcn.2008.45
Source: Web of Science (Lite)
Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.
Authors: Ahrén, B., Mari, A., Fyfe, C.L., Tsofliou, F., Sneddon, A.A., Wahle, K.W., Winzell, M.S., Pacini, G. and Williams, L.M.
Journal: European journal of clinical nutrition
Volume: 63
Issue: 6
Pages: 778-786
eISSN: 1476-5640
ISSN: 0954-3007
DOI: 10.1038/ejcn.2008.45
Abstract:Background/objectives
Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old, lean and obese subjects was tested.Subjects/methods
CLA (3 g daily) plus n-3 LC-PUFA (3 g daily) or control oil (6 g daily) was given to lean (n=12; BMI 20-26 kg/m(2)) or obese (n=10; BMI 29-35 kg/m(2)) young (20-37 years old) or lean (n=16) or obese (n=11) older men (50-65 years) for 12 weeks. The study had a double-blind, placebo-controlled randomized crossover design, and primary end points were insulin secretion and sensitivity during a standardized meal test, evaluated by modeling glucose, insulin and C-peptide data.Results
The combination was well tolerated. There was no significant difference in fasting levels of glucose, insulin or C-peptide after CLA/n-3 LC-PUFA treatment compared with control oil. Neither insulin secretion nor estimated sensitivity was affected by CLA/n-3 LC-PUFA in lean or obese young subjects or in older lean subjects. However, in older obese subjects, estimated insulin sensitivity was reduced with CLA/n-3 LC-PUFA compared with control (P=0.024).Conclusions
The results do not support beneficial effects of CLA/n-3 LC-PUFA for beta-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced.Source: Europe PubMed Central