The airflow resistance sensing threshold during tidal breathing rises in old age in patients with asthma
Authors: Allen, S.C. and Khattab, A.
Journal: Age and Ageing
Volume: 41
Issue: 4
Pages: 557-560
eISSN: 1468-2834
ISSN: 0002-0729
DOI: 10.1093/ageing/afs041
Abstract:Background: in a previous study, we showed that the ability to detect a rise in airflow resistance at rest was reduced in some non-asthmatic subjects in old age.Objective: to determine whether airflow resistance detection is attenuated in elderly subjects with asthma.Methods: we studied 60 adult subjects with stable asthma (age range 20-88). Progressive external airflow resistance loading was used to measure the inspiratory load detection threshold (LDT) during tidal breathing at rest. Results: the mean inspiratory LDT was 5.57 (4.33 SD) kPa.s/l in the 20-64 age group (n = 32) and 15.6 (10.1 SD) kPa.s/l in those aged 65 and above (n = 28) (P < 0.0001). The inspiratory LDT was significantly correlated with age (r = 0.5246, P < 0.00008), mainly due to the effect of higher LDTs in about half of the subjects above the age of 65 years. Expiratory LDT values and correlations were very similar to inspiratory values. Conclusions: the threshold for detecting external resistive loads during tidal breathing rises in old age in some, but not all, asthmatic patients as was observed in non-asthmatic subjects. The finding has implications for treatment guidelines because some elderly subjects are likely to have reduced awareness of worsening airflow obstruction, and consequently delay their use of rescue treatments. © The Author 2012. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
Source: Scopus
The airflow resistance sensing threshold during tidal breathing rises in old age in patients with asthma.
Authors: Allen, S.C. and Khattab, A.
Journal: Age Ageing
Volume: 41
Issue: 4
Pages: 557-560
eISSN: 1468-2834
DOI: 10.1093/ageing/afs041
Abstract:BACKGROUND: in a previous study, we showed that the ability to detect a rise in airflow resistance at rest was reduced in some non-asthmatic subjects in old age. OBJECTIVE: to determine whether airflow resistance detection is attenuated in elderly subjects with asthma. METHODS: we studied 60 adult subjects with stable asthma (age range 20-88). Progressive external airflow resistance loading was used to measure the inspiratory load detection threshold (LDT) during tidal breathing at rest. RESULTS: the mean inspiratory LDT was 5.57 (4.33 SD) kPa.s/l in the 20-64 age group (n=32) and 15.6 (10.1 SD) kPa.s/l in those aged 65 and above (n=28) (P<0.0001). The inspiratory LDT was significantly correlated with age (r=0.5246, P<0.00008), mainly due to the effect of higher LDTs in about half of the subjects above the age of 65 years. Expiratory LDT values and correlations were very similar to inspiratory values. CONCLUSIONS: the threshold for detecting external resistive loads during tidal breathing rises in old age in some, but not all, asthmatic patients as was observed in non-asthmatic subjects. The finding has implications for treatment guidelines because some elderly subjects are likely to have reduced awareness of worsening airflow obstruction, and consequently delay their use of rescue treatments.
Source: PubMed
Preferred by: Ahmed Khattab and Stephen Allen
The airflow resistance sensing threshold during tidal breathing rises in old age in patients with asthma
Authors: Allen, S.C. and Khattab, A.
Journal: AGE AND AGEING
Volume: 41
Issue: 4
Pages: 557-560
eISSN: 1468-2834
ISSN: 0002-0729
DOI: 10.1093/ageing/afs041
Source: Web of Science (Lite)
The airflow resistance sensing threshold during tidal breathing rises in old age in patients with asthma.
Authors: Allen, S.C. and Khattab, A.
Journal: Age and ageing
Volume: 41
Issue: 4
Pages: 557-560
eISSN: 1468-2834
ISSN: 0002-0729
DOI: 10.1093/ageing/afs041
Abstract:Background
in a previous study, we showed that the ability to detect a rise in airflow resistance at rest was reduced in some non-asthmatic subjects in old age.Objective
to determine whether airflow resistance detection is attenuated in elderly subjects with asthma.Methods
we studied 60 adult subjects with stable asthma (age range 20-88). Progressive external airflow resistance loading was used to measure the inspiratory load detection threshold (LDT) during tidal breathing at rest.Results
the mean inspiratory LDT was 5.57 (4.33 SD) kPa.s/l in the 20-64 age group (n=32) and 15.6 (10.1 SD) kPa.s/l in those aged 65 and above (n=28) (P<0.0001). The inspiratory LDT was significantly correlated with age (r=0.5246, P<0.00008), mainly due to the effect of higher LDTs in about half of the subjects above the age of 65 years. Expiratory LDT values and correlations were very similar to inspiratory values.Conclusions
the threshold for detecting external resistive loads during tidal breathing rises in old age in some, but not all, asthmatic patients as was observed in non-asthmatic subjects. The finding has implications for treatment guidelines because some elderly subjects are likely to have reduced awareness of worsening airflow obstruction, and consequently delay their use of rescue treatments.Source: Europe PubMed Central