A possible mechanism of action of danazol and an ethinylestradiol/norgestrel combination used as postcoital contraceptive agents.

Authors: Rowlands, S., Kubba, A.A., Guillebaud, J. and Bounds, W.

Journal: Contraception

Volume: 33

Issue: 6

Pages: 539-545

ISSN: 0010-7824

DOI: 10.1016/0010-7824(86)90042-9

Abstract:

Twenty-seven women requesting postcoital contraception were randomly allocated to take an ethinylestradiol/dl-norgestrel combination or danazol. Urine specimens were assayed for luteinising hormone (LH) and pregnanediol-3-glucuronide (P3G) levels from the day of the postcoital treatment to the next period. In addition, the urine samples of these recruits and 12 additional women were assayed for the Beta-subunit of human chorionic gonadotropin (B-hCG). A consistent pattern of alteration in urinary steroids was lacking, indicating a heterogeneous effect on ovarian function. There was no evidence of early pregnancy in successfully treated cases. We suggest that the main mechanism of action of these drugs is at the endometrial level.

Source: PubMed

A POSSIBLE MECHANISM OF ACTION OF DANAZOL AND AN ETHINYLESTRADIOL NORGESTREL COMBINATION USED AS POSTCOITAL CONTRACEPTIVE AGENTS

Authors: ROWLANDS, S., KUBBA, A.A., GUILLEBAUD, J. and BOUNDS, W.

Journal: CONTRACEPTION

Volume: 33

Issue: 6

Pages: 539-545

ISSN: 0010-7824

DOI: 10.1016/0010-7824(86)90042-9

Source: Web of Science (Lite)

A possible mechanism of action of danazol and an ethinylestradiol/norgestrel combination used as postcoital contraceptive agents.

Authors: Rowlands, S., Kubba, A.A., Guillebaud, J. and Bounds, W.

Journal: Contraception

Volume: 33

Issue: 6

Pages: 539-545

eISSN: 1879-0518

ISSN: 0010-7824

DOI: 10.1016/0010-7824(86)90042-9

Abstract:

Twenty-seven women requesting postcoital contraception were randomly allocated to take an ethinylestradiol/dl-norgestrel combination or danazol. Urine specimens were assayed for luteinising hormone (LH) and pregnanediol-3-glucuronide (P3G) levels from the day of the postcoital treatment to the next period. In addition, the urine samples of these recruits and 12 additional women were assayed for the Beta-subunit of human chorionic gonadotropin (B-hCG). A consistent pattern of alteration in urinary steroids was lacking, indicating a heterogeneous effect on ovarian function. There was no evidence of early pregnancy in successfully treated cases. We suggest that the main mechanism of action of these drugs is at the endometrial level.

Source: Europe PubMed Central