As time flies by: Investigating cardiac aging in the short-lived Drosophila model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.
Journal: Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Scopus
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.
Journal: Biochim Biophys Acta Mol Basis Dis
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: PubMed
As time flies by: Investigating cardiac aging in the short-lived <i>Drosophila</i> model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
https://eprints.bournemouth.ac.uk/31626/
Source: Web of Science (Lite)
As time flies by: Investigating cardiac aging in the short-lived Drosophila model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P., Adams, P., Bodmer, R. and Cammarato, A.
Journal: BBA - Molecular Basis of Disease
ISSN: 0925-4439
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Manual
Preferred by: Paul Hartley
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.
Journal: Biochimica et biophysica acta. Molecular basis of disease
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Europe PubMed Central
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume: 1865
Issue: 7
Pages: 1831-1844
ISSN: 0925-4439
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: BURO EPrints