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As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.

Journal: Biochimica et Biophysica Acta - Molecular Basis of Disease

Volume: 1865

Issue: 7

Pages: 1831-1844

eISSN: 1879-260X

ISSN: 0925-4439

DOI: 10.1016/j.bbadis.2018.11.010

Abstract:

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

https://eprints.bournemouth.ac.uk/31626/

Source: Scopus

As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.

Journal: Biochim Biophys Acta Mol Basis Dis

Volume: 1865

Issue: 7

Pages: 1831-1844

eISSN: 1879-260X

DOI: 10.1016/j.bbadis.2018.11.010

Abstract:

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

https://eprints.bournemouth.ac.uk/31626/

Source: PubMed

As time flies by: Investigating cardiac aging in the short-lived <i>Drosophila</i> model

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.

Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Volume: 1865

Issue: 7

Pages: 1831-1844

eISSN: 1879-260X

ISSN: 0925-4439

DOI: 10.1016/j.bbadis.2018.11.010

https://eprints.bournemouth.ac.uk/31626/

Source: Web of Science (Lite)

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P., Adams, P., Bodmer, R. and Cammarato, A.

Journal: BBA - Molecular Basis of Disease

ISSN: 0925-4439

Abstract:

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

https://eprints.bournemouth.ac.uk/31626/

Source: Manual

Preferred by: Paul Hartley

As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Volume: 1865

Issue: 7

Pages: 1831-1844

eISSN: 1879-260X

ISSN: 0925-4439

DOI: 10.1016/j.bbadis.2018.11.010

Abstract:

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

https://eprints.bournemouth.ac.uk/31626/

Source: Europe PubMed Central

As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R. and Cammarato, A.

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Volume: 1865

Issue: 7

Pages: 1831-1844

ISSN: 0925-4439

Abstract:

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

https://eprints.bournemouth.ac.uk/31626/

Source: BURO EPrints