Triggering of TNFRSF25 promotes CD8 <sup>+</sup> T-cell responses and anti-tumor immunity
Authors: Slebioda, T.J., Rowley, T.F., Ferdinand, J.R., Willoughby, J.E., Buchan, S.L., Taraban, V.Y. and Al-Shamkhani, A.
Journal: European Journal of Immunology
Volume: 41
Issue: 9
Pages: 2606-2611
eISSN: 1521-4141
ISSN: 0014-2980
DOI: 10.1002/eji.201141477
Abstract:TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF-like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4 + T-cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8 + T cells. Here, we demonstrate that ectopic expression of TL1A on mouse plasmacytomas promotes elimination of tumor cells in a CD8 + T-cell-dependent manner and renders mice immune to a subsequent challenge with tumor cells. To gain further insight into the role of TNFRSF25 in CD8 + T-cell responses, we analyzed the effect of TNFRSF25 triggering on OT-I TCR transgenic T cells. We demonstrate that TNFRSF25 triggering in vivo with soluble TL1A promotes the proliferation and accumulation of antigen-specific CD8 + T cells as well as their differentiation into CTLs. Furthermore, we show that TNFRSF25 also functions as a costimulatory receptor for memory CD8 + T cells. Thus, TNFRSF25 triggering enhances the secondary expansion of endogenous antigen-specific memory CD8 + T cells. Our data suggest that TNFRSF25 agonists, such as soluble TL1A, could potentially be used to enhance the immunogenicity of vaccines that aim to elicit human anti-tumor CD8 + T cells. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source: Scopus
Triggering of TNFRSF25 promotes CD8⁺ T-cell responses and anti-tumor immunity.
Authors: Slebioda, T.J., Rowley, T.F., Ferdinand, J.R., Willoughby, J.E., Buchan, S.L., Taraban, V.Y. and Al-Shamkhani, A.
Journal: Eur J Immunol
Volume: 41
Issue: 9
Pages: 2606-2611
eISSN: 1521-4141
DOI: 10.1002/eji.201141477
Abstract:TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF-like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4(+) T-cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8(+) T cells. Here, we demonstrate that ectopic expression of TL1A on mouse plasmacytomas promotes elimination of tumor cells in a CD8(+) T-cell-dependent manner and renders mice immune to a subsequent challenge with tumor cells. To gain further insight into the role of TNFRSF25 in CD8(+) T-cell responses, we analyzed the effect of TNFRSF25 triggering on OT-I TCR transgenic T cells. We demonstrate that TNFRSF25 triggering in vivo with soluble TL1A promotes the proliferation and accumulation of antigen-specific CD8(+) T cells as well as their differentiation into CTLs. Furthermore, we show that TNFRSF25 also functions as a costimulatory receptor for memory CD8(+) T cells. Thus, TNFRSF25 triggering enhances the secondary expansion of endogenous antigen-specific memory CD8(+) T cells. Our data suggest that TNFRSF25 agonists, such as soluble TL1A, could potentially be used to enhance the immunogenicity of vaccines that aim to elicit human anti-tumor CD8(+) T cells.
Source: PubMed
Triggering of TNFRSF25 promotes CD8<SUP>+</SUP> T-cell responses and anti-tumor immunity
Authors: Slebioda, T.J., Rowley, T.F., Ferdinand, J.R., Willoughby, J.E., Buchan, S.L., Taraban, V.Y. and Al-Shamkhani, A.
Journal: EUROPEAN JOURNAL OF IMMUNOLOGY
Volume: 41
Issue: 9
Pages: 2606-2611
ISSN: 0014-2980
DOI: 10.1002/eji.201141477
Source: Web of Science (Lite)
Triggering of TNFRSF25 promotes CD8⁺ T-cell responses and anti-tumor immunity.
Authors: Slebioda, T.J., Rowley, T.F., Ferdinand, J.R., Willoughby, J.E., Buchan, S.L., Taraban, V.Y. and Al-Shamkhani, A.
Journal: European journal of immunology
Volume: 41
Issue: 9
Pages: 2606-2611
eISSN: 1521-4141
ISSN: 0014-2980
DOI: 10.1002/eji.201141477
Abstract:TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF-like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4(+) T-cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8(+) T cells. Here, we demonstrate that ectopic expression of TL1A on mouse plasmacytomas promotes elimination of tumor cells in a CD8(+) T-cell-dependent manner and renders mice immune to a subsequent challenge with tumor cells. To gain further insight into the role of TNFRSF25 in CD8(+) T-cell responses, we analyzed the effect of TNFRSF25 triggering on OT-I TCR transgenic T cells. We demonstrate that TNFRSF25 triggering in vivo with soluble TL1A promotes the proliferation and accumulation of antigen-specific CD8(+) T cells as well as their differentiation into CTLs. Furthermore, we show that TNFRSF25 also functions as a costimulatory receptor for memory CD8(+) T cells. Thus, TNFRSF25 triggering enhances the secondary expansion of endogenous antigen-specific memory CD8(+) T cells. Our data suggest that TNFRSF25 agonists, such as soluble TL1A, could potentially be used to enhance the immunogenicity of vaccines that aim to elicit human anti-tumor CD8(+) T cells.
Source: Europe PubMed Central