Sarah Buchan

Dr Sarah Buchan

  • Principal Academic in Immunology
  • Christchurch House C211, Talbot Campus, Fern Barrow, Poole, BH12 5BB
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Biography

My research interests centre on understanding the regulation of the adaptive immune system. Specific long-term interests revolve around how T cells can be exploited to enhance cancer immunotherapy and alleviate dysregulation. Currently I have two ongoing projects investigating different aspects of adaptive responses in cancer. The first is seeking to characterise CMV-specific T cells after bone marrow transplant in order to improve patient monitoring, a collaboration with Southampton University Hospitals Trust (see here for a video describing the project: https://www.youtube.com/watch?v=WiNBCm1uSHk). The second project is investigating the immune microenvironment in Waldenstrom's macroglobulineamia (a type of lymphoma) patients to understand how current treatment approaches impact disease; this is in collaboration with University Hospitals Dorset. Other ongoing research projects are investigating the role of T cells in infertility and exploring the impact of our environment on immune function in humans and other species...

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Favourites

  • Buchan, S.L. et al., 2018. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity, 49 (5), 958-970.e7.

Journal Articles

  • Buchan, S.L., 2024. CTLA-4: Checkpoints beyond the membrane. Mol Ther, 32 (2), 279-281.
  • Buchan, S., 2024. CTLA-4 - beyond the membrane. Molecular Therapy.
  • Smith, E. and Buchan, S., 2023. Skewed perception of personal behaviour as a contributor to antibiotic resistance and underestimation of the risks. PLoS ONE, 18 (11 October).
  • Dadas, O., Allen, J.D., Buchan, S.L., Kim, J., Chan, H.T.C., Mockridge, C.I., Duriez, P.J., Rogel, A., Crispin, M. and Al-Shamkhani, A., 2023. Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc. Frontiers in Immunology, 14.
  • Nickbakhsh, S. et al., 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports, 12 (1).
  • Rogel, A., Ibrahim, F.M., Thirdborough, S.M., Renart-Depontieu, F., Birts, C.N., Buchan, S.L., Preville, X., King, E.V. and Al-Shamkhani, A., 2022. Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies. JCI Insight, 7 (19).
  • Willett, B.J., Mantzouratou, A., Buchan, S.L. et al., 2022. Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (Nature Microbiology, (2022), 7, 8, (1161-1179), 10.1038/s41564-022-01143-7). Nature Microbiology, 7 (10), 1709.
  • Willett, B.J., Mantzouratou, A., Buchan, S.L. et al., 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7 (8), 1161-1179.
  • Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A., 2022. Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes. European Journal of Obstetrics and Gynecology and Reproductive Biology, 274, 229-237.
  • Kläser, K., Buchan, S.L., Mantzouratou, A. et al., 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports, 12 (1).
  • de Silva, T.I., Buchan, S.L. et al., 2021. The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24 (11).
  • Buchan, S.L. et al., 2018. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity, 49 (5), 958-970.e7.
  • Buchan, S.L. et al., 2018. PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity. Clin Cancer Res, 24 (10), 2383-2394.
  • Rogel, A., Willoughby, J.E., Buchan, S.L., Leonard, H.J., Thirdborough, S.M. and Al-Shamkhani, A., 2018. Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance. Proc Natl Acad Sci U S A, 114 (7), E1178-E1187.
  • Buchan, S.L., Rogel, A. and Al-Shamkhani, A., 2017. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood, 131 (1), 39-48.
  • Buchan, S.L. et al., 2015. OX40- and CD27-Mediated costimulation synergizes with Anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. Journal of Immunology, 194 (1), 125-133.
  • Willoughby, J.E., Kerr, J.P., Rogel, A., Taraban, V.Y., Buchan, S.L., Johnson, P.W.M. and Al-Shamkhani, A., 2014. Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization. Journal of Immunology, 193 (1), 244-251.
  • Hardwick, N., Buchan, S., Ingram, W., Khan, G., Vittes, G., Rice, J., Pulford, K., Mufti, G., Stevenson, F. and Guinn, B.A., 2013. An analogue peptide from the cancer/testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide. Cancer Immunity, 13 (3).
  • Taraban, V.Y., Rowley, T.F., Kerr, J.P., Willoughby, J.E., Johnson, P.M.W., Al-Shamkhani, A. and Buchan, S.L., 2013. CD27 costimulation contributes substantially to the expansion of functional memory CD8+ T cells after peptide immunization. European Journal of Immunology, 43 (12), 3314-3323.
  • Buchan, S.L. and Al-Shamkhani, A., 2012. Distinct Motifs in the Intracellular Domain of Human CD30 Differentially Activate Canonical and Alternative Transcription Factor NF-κB Signaling. PLoS ONE, 7 (9).
  • Buchan, S.L., Taraban, V.Y., Slebioda, T.J., James, S., Cunningham, A.F. and Al-Shamkhani, A., 2012. Death receptor 3 is essential for generating optimal protective CD4 1 T-cell immunity against Salmonella. European Journal of Immunology, 42 (3), 580-588.
  • Slebioda, T.J., Rowley, T.F., Ferdinand, J.R., Willoughby, J.E., Buchan, S.L., Taraban, V.Y. and Al-Shamkhani, A., 2011. Triggering of TNFRSF25 promotes CD8 + T-cell responses and anti-tumor immunity. European Journal of Immunology, 41 (9), 2606-2611.
  • Taraban, V.Y., Slebioda, T.J., Willoughby, J.E., Buchan, S.L., James, S., Sheth, B., Smyth, N.R., Thomas, G.J., Wang, E.C.Y. and Al-Shamkhani, A., 2011. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology, 4 (2), 186-196.
  • Chaise, C. et al., 2008. DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood, 112 (7), 2956-2964.
  • Rice, J., Dossett, M.L., Öhlén, C., Buchan, S.L., Kendall, T.J., Dunn, S.N., Stevenson, F.K. and Greenberg, P.D., 2008. DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire. European Journal of Immunology, 38 (8), 2118-2130.
  • Rice, J., Dunn, S., Piper, K., Buchan, S.L., Moss, P.A. and Stevenson, F.K., 2006. DNA fusion vaccines induce epitope-specific cytotoxic CD8+ T cells against human leukemia-associated minor histocompatibility antigens. Cancer Research, 66 (10), 5436-5442.
  • Buchan, S., Grønevik, E., Mathiesen, I., King, C.A., Stevenson, F.K. and Rice, J., 2005. Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen. Journal of Immunology, 174 (10), 6292-6298.
  • Stevenson, F.K., Buchan, S.L. et al., 2004. DNA vaccines to attack cancer. Proceedings of the National Academy of Sciences of the United States of America, 101 (SUPPL. 2), 14646-14652.
  • Rice, J., Buchan, S., Dewchand, H., Simpson, E. and Stevenson, F.K., 2004. DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire. Journal of Immunology, 173 (7), 4492-4499.
  • Mockridge, C.I., Rahman, A., Buchan, S., Hamblin, T., Isenberg, D.A., Stevenson, F.K. and Potter, K.N., 2004. Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection. Autoimmunity, 37 (1), 9-15.
  • Potter, K.N., Mockridgel, C.I., Rahman, A., Buchan, S., Hamblin, T., Davidson, B., Isenberg, D.A. and Stevenson, F.K., 2002. Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus, 11 (12), 872-877.
  • Rice, J., Buchan, S. and Stevenson, F.K., 2002. Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen1. Journal of Immunology, 169 (7), 3908-3913.
  • Wilkins, B.S., Buchan, S.L., Webster, J. and Jones, D.B., 2001. Tryptase-positive mast cells accompany lymphocytic as well as lymphoplasmacytic lymphoma infiltrates in bone marrow trephine biopsies. Histopathology, 39 (2), 150-155.
  • Rice, J., Elliott, T., Buchan, S. and Stevenson, F.K., 2001. DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: Implications for cancer vaccines. Journal of Immunology, 167 (3), 1558-1565.

Conferences

  • Christian, A., Davis, Z., Walewska, R., Buchan, S., Sabeur, Z. and McCarthy, H., 2024. Data Analytics of Treatment effects on Immune Response Pathways within the Tumour Microenvironment of Waldenström Macroglobulinaemia. In: Cambridge lymphoma biology international symposium 2024 17-18 September 2024 Cambridge.
  • Christian, A., Davis, Z., Walewska, R., Buchan, S., Sabeur, Z. and McCarthy, H., 2024. Data Analytics of Treatment effects on Immune Response Pathways within the Tumour Microenvironment of Waldenström Macroglobulinaemia. In: International Workshop on Waldenstrom's macroglobulinaemia 17-19 October 2024 Prague.
  • Willis, S., Neal, R., Mantzouratou, A., Pelosi, E. and Buchan, S., 2024. Detecting and Defining Immunity to human cytomegalovirus. In: BSI Immune-stromal interactions in health and disease 14 June 2024 Southampton University Hospitals Trust.
  • Willis, S., Neal, R., Mantzouratou, A., Emanuela, P. and Buchan, S., 2023. Detecting and defining immunity to cytomegalovirus. In: British Society for Immunology Annual Congress 5-8 December 2023 Belfast.
  • Parker, B., Amelia, W., Britton, R., Andreou, D. and Buchan, S., 2023. Fish immunity in a warming world. In: British Society for Immunology Annual Conference 5-8 December 2023 Belfast.

Posters

PhD Students

  • Amy Christian, (In progress)
  • Jack Wieland

Profile of Teaching PG

  • MRes student Sophie Willis 22-23

Profile of Teaching UG

  • Introduction to Immunology
  • Advanced Immunology
  • Pathophysiology

Invited Lectures

  • Role of vaccines for COVID-19, Remote, 11 Apr 2022 more

Grants

  • Ensuring meaningful Patient and Public Input in a clinical study tracking immunity to cytomegalovirus in allogeneic bone marrow transplant patients (British Society for Immunology, 31 Oct 2023). Awarded
  • Engaging with immunology in a time of COVID-19 (BSI, 01 May 2022). Awarded
  • Travel grant; Cancer Immunotherapy Conference (British Society for Immunology, 10 Mar 2019). Completed

External Responsibilities

Internal Responsibilities

  • Member, LES Research Committee
  • Member, Human Tissue Licencing Sub-committee

Conference Presentations

  • Keystone: Cancer Immunotherapy, PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity, 10 Mar 2019, Whistler, British Columbia, Canada

Memberships

  • British Society of Immunology, Member (2013-),
  • Covid-19 Genomics UK Consortium (COG-UK), Member,
  • Higher Education Academy, Fellow,
  • Institute of Biomedical Scientists, Fellow,