Sarah Buchan

Dr Sarah Buchan

  • Lecturer In Immunology
  • Christchurch House C211, Talbot Campus, Fern Barrow, Poole, BH12 5BB
Back to top


  • Buchan, S.L. et al., 2018. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity, 49 (5), 958-970.e7.

Journal Articles

  • Buchan, S.L. et al., 2018. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity, 49 (5), 958-970.e7.
  • Buchan, S.L. et al., 2018. PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity. Clin Cancer Res, 24 (10), 2383-2394.
  • Rogel, A., Willoughby, J.E., Buchan, S.L., Leonard, H.J., Thirdborough, S.M. and Al-Shamkhani, A., 2018. Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance. Proc Natl Acad Sci U S A, 114 (7), E1178-E1187.
  • Buchan, S.L., Rogel, A. and Al-Shamkhani, A., 2017. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood, 131 (1), 39-48.
  • Buchan, S. et al., 2015. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol, 194 (1), 125-133.
  • Taraban, V.Y., Rowley, T.F., Kerr, J.P., Willoughby, J.E., Johnson, P.M.W., Al-Shamkhani, A. and Buchan, S.L., 2013. CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization. Eur J Immunol, 43 (12), 3314-3323.
  • Buchan, S.L., Taraban, V.Y., Slebioda, T.J., James, S., Cunningham, A.F. and Al-Shamkhani, A., 2012. Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella. Eur J Immunol, 42 (3), 580-588.
  • Buchan, S.L. and Al-Shamkhani, A., 2012. Distinct motifs in the intracellular domain of human CD30 differentially activate canonical and alternative transcription factor NF-κB signaling. PLoS One, 7 (9), e45244.
  • Taraban, V.Y., Slebioda, T.J., Willoughby, J.E., Buchan, S.L., James, S., Sheth, B., Smyth, N.R., Thomas, G.J., Wang, E.C.Y. and Al-Shamkhani, A., 2011. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunol, 4 (2), 186-196.
  • Rice, J., Dossett, M.L., Ohlén, C., Buchan, S.L., Kendall, T.J., Dunn, S.N., Stevenson, F.K. and Greenberg, P.D., 2008. DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire. Eur J Immunol, 38 (8), 2118-2130.
  • Rice, J., Dunn, S., Piper, K., Buchan, S.L., Moss, P.A. and Stevenson, F.K., 2006. DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens. Cancer Res, 66 (10), 5436-5442.
  • Stevenson, F.K., Buchan, S.L. et al., 2004. DNA vaccines to attack cancer. Proc Natl Acad Sci U S A, 101 Suppl 2, 14646-14652.
  • Rice, J., Buchan, S., Dewchand, H., Simpson, E. and Stevenson, F.K., 2004. DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire. J Immunol, 173 (7), 4492-4499.
  • Mockridge, C.I., Rahman, A., Buchan, S., Hamblin, T., Isenberg, D.A., Stevenson, F.K. and Potter, K.N., 2004. Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection. Autoimmunity, 37 (1), 9-15.
  • Rice, J., Buchan, S. and Stevenson, F.K., 2002. Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen. J Immunol, 169 (7), 3908-3913.
  • Potter, K.N., Mockridge, C.I., Rahman, A., Buchan, S., Hamblin, T., Davidson, B., Isenberg, D.A. and Stevenson, F.K., 2002. Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus, 11 (12), 872-877.
  • Wilkins, B.S., Buchan, S.L., Webster, J. and Jones, D.B., 2001. Tryptase-positive mast cells accompany lymphocytic as well as lymphoplasmacytic lymphoma infiltrates in bone marrow trephine biopsies. Histopathology, 39 (2), 150-155.
  • Rice, J., Elliott, T., Buchan, S. and Stevenson, F.K., 2001. DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: implications for cancer vaccines. J Immunol, 167 (3), 1558-1565.


  • Travel grant; Cancer Immunotherapy Conference (British Society for Immunology, 10 Mar 2019). Completed

External Responsibilities

Conference Presentations

  • Keystone: Cancer Immunotherapy, PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity, 10 Mar 2019, Whistler, British Columbia, Canada


  • British Society of Immunology, Member (2013-),