The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus
Authors: Czosnyka, Z., Van Den Boogaard, F., Czosnyka, M., Momjian, S., Gelling, L. and Pickard, J.D.
Journal: Acta Neurochirurgica, Supplementum
Issue: 95
Pages: 207-211
ISSN: 0065-1419
DOI: 10.1007/3-211-32318-X_43
Abstract:Previously, we documented association between CSF circulation and transcranial-Doppler derived autoregulation in non-shunted patients suffering from hydrocephalus. In the present study we sought to investigate the relationship between the resistance to CSF outflow and pressure-reactivity both in shunted and non-shunted NPH patients. Sixty-eight patients (47 non-shunted and 21 shunted) with NPH have been examined as a part of routine diagnostic procedure. Resistance to CSF outflow (Rcsf) was measured using a ventricular constant rate infusion test. Cerebrovascular pressure-reactivity was assessed as a moving correlation coefficient (PRx) between coherent 'slow waves' of ICP and arterial blood pressure (ABP). This variable has previously been demonstrated to correlate with the autoregulation of CBF in patients following head injury. In non-shunted patients cerebrovascular pressure-reactivity (PRx) was negatively correlated with Rcsf (R = -0.5; p < 0.0005). This relationship was inverted in shunted patients: a positive correlation between PRx and Rcsf was found (R = 0.51; p < 0.03). Cerebrovascular pressure-reactivity is disturbed in patients with normal resistance to CSF outflow, suggesting underlying cerebrovascular disease. This result confirms our previous finding where transcranial Doppler autoregulation was investigated. After shunting the pressure-reactivity strongly depends on shunt functioning and deteriorates when the shunt is blocked. © 2005 Springer-Verlag.
Source: Scopus
The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus.
Authors: Czosnyka, Z., van den Boogaard, F., Czosnyka, M., Momjian, S., Gelling, L. and Pickard, J.D.
Journal: Acta Neurochir Suppl
Volume: 95
Pages: 207-211
ISSN: 0065-1419
DOI: 10.1007/3-211-32318-x_43
Abstract:OBJECTIVE: Previously, we documented association between CSF circulation and transcranial-Doppler derived autoregulation in non-shunted patients suffering from hydrocephalus. In the present study we sought to investigate the relationship between the resistance to CSF outflow and pressure-reactivity both in shunted and non-shunted NPH patients. MATERIAL AND METHODS: Sixty-eight patients (47 non-shunted and 21 shunted) with NPH have been examined as a part of routine diagnostic procedure. Resistance to CSF outflow (Rcsf) was measured using a ventricular constant rate infusion test. Cerebrovascular pressure-reactivity was assessed as a moving correlation coefficient (PRx) between coherent 'slow waves' of ICP and arterial blood pressure (ABP). This variable has previously been demonstrated to correlate with the autoregulation of CBF in patients following head injury. Results. In non-shunted patients cerebrovascular pressure-reactivity (PRx) was negatively correlated with Rcsf (R = -0.5; p < 0.0005). This relationship was inverted in shunted patients: a positive correlation between PRx and Rcsf was found (R = 0.51; p < 0.03). CONCLUSION: Cerebrovascular pressure-reactivity is disturbed in patients with normal resistance to CSF outflow, suggesting underlying cerebrovascular disease. This result confirms our previous finding where transcranial Doppler autoregulation was investigated. After shunting the pressure-reactivity strongly depends on shunt functioning and deteriorates when the shunt is blocked.
Source: PubMed
The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus
Authors: Czosnyka, Z., van den Boogaard, F., Czosnyka, M., Momjian, S., Gelling, L. and Pickard, J.D.
Journal: Intracranial Pressure and Brain Monitoring XII
Volume: 95
Pages: 207-211
ISSN: 0065-1419
Source: Web of Science (Lite)
The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus.
Authors: Czosnyka, Z., van den Boogaard, F., Czosnyka, M., Momjian, S., Gelling, L. and Pickard, J.D.
Journal: Acta neurochirurgica. Supplement
Volume: 95
Pages: 207-211
ISSN: 0065-1419
DOI: 10.1007/3-211-32318-x_43
Abstract:Objective
Previously, we documented association between CSF circulation and transcranial-Doppler derived autoregulation in non-shunted patients suffering from hydrocephalus. In the present study we sought to investigate the relationship between the resistance to CSF outflow and pressure-reactivity both in shunted and non-shunted NPH patients.Material and methods
Sixty-eight patients (47 non-shunted and 21 shunted) with NPH have been examined as a part of routine diagnostic procedure. Resistance to CSF outflow (Rcsf) was measured using a ventricular constant rate infusion test. Cerebrovascular pressure-reactivity was assessed as a moving correlation coefficient (PRx) between coherent 'slow waves' of ICP and arterial blood pressure (ABP). This variable has previously been demonstrated to correlate with the autoregulation of CBF in patients following head injury. Results. In non-shunted patients cerebrovascular pressure-reactivity (PRx) was negatively correlated with Rcsf (R = -0.5; p < 0.0005). This relationship was inverted in shunted patients: a positive correlation between PRx and Rcsf was found (R = 0.51; p < 0.03).Conclusion
Cerebrovascular pressure-reactivity is disturbed in patients with normal resistance to CSF outflow, suggesting underlying cerebrovascular disease. This result confirms our previous finding where transcranial Doppler autoregulation was investigated. After shunting the pressure-reactivity strongly depends on shunt functioning and deteriorates when the shunt is blocked.Source: Europe PubMed Central