Modulation of fasted and postprandial plasma lipids in healthy volunteers byadietary mixture of omega-3 fatty acids and conjugated linoleic acid

Authors: Tsofliou, F., Fyfe, C.L., Matheson, I., Jackson, D.M., Horgan, G.W., Wahle, K.W.J., Ahren, B., Williams, L.M. and Sneddon, A.A.

Journal: Journal of Food Lipids

Volume: 16

Issue: 4

Pages: 499-513

eISSN: 1745-4522

ISSN: 1065-7258

DOI: 10.1111/j.1745-4522.2009.01162.x

Abstract:

Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In © 2009, Wiley Periodicals, Inc.

Source: Scopus

Preferred by: Fotini Tsofliou