Sensing wounds by spilling cellular guts: Damage-associated protease release can initiate tissue repair

Authors: Diaz-de-la-Loza, M.D.C., Matsubayashi, Y. and Stramer, B.M.

Journal: Developmental Cell

Volume: 56

Issue: 15

Pages: 2137-2139

eISSN: 1878-1551

ISSN: 1534-5807

DOI: 10.1016/j.devcel.2021.07.013

Abstract:

Epithelia have an innate yet mysterious capacity to rapidly sense and respond to tissue damage. In this issue of Developmental Cell, O'Connor et al. exploit the genetics of Drosophila to reveal that protease release as a result of tissue injury activates insect cytokines to initiate immediate epithelial repair responses.

Source: Scopus