Yutaka Matsubayashi

Dr Yutaka Matsubayashi

  • Senior Lecturer in Systems Biology
  • Christchurch House C135, Talbot Campus, Fern Barrow, Poole, BH12 5BB
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I obtained my PhD from Kyoto University, Japan, analysing the mechanism of MAP kinase signal transduction. My finding that ERK MAP kinase regulates the collective migration of cultured epithelial cells (Matsubayashi et al. 2004) made me interested in the mechanism of wound healing, for which the coordinated movement of multiple cells is essential. Since then, I have been investigating the mechanism of tissue repair and development using various experimental systems such as cultured cells, mice, and flies. Recently, using the fruit fly Drosophila melanogaster and combining multiple methodologies such as genetics, live microscopy, and mathematical modelling, I am studying the mechanism of the development of the basement membrane, a sheet-like extracellular matrix that is absolutely essential for tissue structure and function.

Journal Articles

  • Matsubayashi, Y., 2023. Mechanical waves help zebrafish regrow their tails. Nature Physics, 19 (9), 1241-1242.
  • Matsubayashi, Y., 2022. Dynamic movement and turnover of extracellular matrices during tissue development and maintenance. Fly, 16 (1), 248-274.
  • Diaz-de-la-Loza, M.D.C., Matsubayashi, Y. and Stramer, B.M., 2021. Sensing wounds by spilling cellular guts: Damage-associated protease release can initiate tissue repair. Developmental Cell, 56 (15), 2137-2139.
  • Marcotti, S., Sánchez-Sánchez, B.J., Serna-Morales, E., Dragu, A., Díaz-de-la-Loza, M.D.C., Matsubayashi, Y. and Stramer, B.M., 2021. Protocol for intervention-free quantification of protein turnover rate by steady-state modeling. STAR Protocols, 2 (1).
  • Matsubayashi, Y., Sánchez-Sánchez, B.J., Marcotti, S., Serna-Morales, E., Dragu, A., Díaz-de-la-Loza, M.D.C., Vizcay-Barrena, G., Fleck, R.A. and Stramer, B.M., 2020. Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis. Developmental Cell, 54 (1), 33-42.e9.
  • de Kerckhove, M., Matsubayashi, Y. et al., 2018. Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. EMBO Molecular Medicine, 10 (10).
  • Gyoergy, A., Roblek, M., Ratheesh, A., Valoskova, K., Belyaeva, V., Wachner, S., Matsubayashi, Y., Sánchez-Sánchez, B.J., Stramer, B. and Siekhaus, D.E., 2018. Tools allowing independent visualization and genetic manipulation of Drosophila melanogaster macrophages and surrounding tissues. G3: Genes, Genomes, Genetics, 8 (3), 845-857.
  • Matsubayashi, Y. et al., 2017. A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation. Current Biology, 27 (22), 3526-3534.e4.
  • Matsubayashi, Y. and Millard, T.H., 2016. Analysis of the Molecular Mechanisms of Reepithelialization in Drosophila Embryos. Adv Wound Care (New Rochelle), 5 (6), 243-250.
  • Matsubayashi, Y., Coulson-Gilmer, C. and Millard, T.H., 2015. Endocytosis-dependent coordination of multiple actin regulators is required for wound healing. J Cell Biol, 210 (3), 419-433.
  • Matsubayashi, Y., Razzell, W. and Martin, P., 2011. 'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion. J Cell Sci, 124 (Pt 7), 1017-1021.
  • Sehara, K., Toda, T., Iwai, L., Wakimoto, M., Tanno, K., Matsubayashi, Y. and Kawasaki, H., 2010. Whisker-related axonal patterns and plasticity of layer 2/3 neurons in the mouse barrel cortex. J Neurosci, 30 (8), 3082-3092.
  • Matsubayashi, Y., Iwai, L., Toda, T., Lu, Q.R. and Kawasaki, H., 2009. Immunostaining for oligodendrocyte-specific galactosphingolipids in fixed brain sections using the cholesterol-selective detergent digitonin. J Neurosci Methods, 178 (1), 87-98.
  • Matsubayashi, Y., Iwai, L. and Kawasaki, H., 2008. Fluorescent double-labeling with carbocyanine neuronal tracing and immunohistochemistry using a cholesterol-specific detergent digitonin. J Neurosci Methods, 174 (1), 71-81.
  • Toda, T., Hayakawa, I., Matsubayashi, Y., Tanaka, K., Ikenaka, K., Lu, Q.R. and Kawasaki, H., 2008. Termination of lesion-induced plasticity in the mouse barrel cortex in the absence of oligodendrocytes. Mol Cell Neurosci, 39 (1), 40-49.
  • Matsubayashi, Y., Ebisuya, M., Honjoh, S. and Nishida, E., 2004. ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol, 14 (8), 731-735.
  • Ogawa, S., Matsubayashi, Y. and Nishida, E., 2004. An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans. Genes Cells, 9 (2), 83-93.
  • Matsubayashi, Y. and Nishida, E., 2002. [Regulating mechanisms and functions of MAP kinases]. Tanpakushitsu Kakusan Koso, 47 (11), 1399-1403.
  • Matsubayashi, Y., Fukuda, M. and Nishida, E., 2001. Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J Biol Chem, 276 (45), 41755-41760.

Profile of Teaching UG

  • Advanced Systems Biology
  • Introduction to Biology
  • Evolutionary Biology
  • Exploring and Understanding Sciene
  • Introduction to Clinical Genetics


  • Investigating the mechanisms that orchestrate basement membrane formation – toward the invention of future therapies (The Academy of Medical Sciences, 01 May 2023). Awarded

External Responsibilities

  • FY2023-2027 MEXT KAKENHI Grant-in-Aid for Transformative Research Area (A), 'Integration of Extracellular Information by Multimodal ECM Activity', Advisor (2023-2027), https://www.multimodal-ecm.com/

Public Engagement & Outreach Activities

  • Café Scientifique – The hidden life of white blood cells: how they help construct our bodies (07 Nov 2023)


  • PhD in Molecular Cell Biology (Kyoto University, Japan, 2004)
  • BSc (Hons) in Science (Kyoto University, Japan, 1999)


  • Advance HE (former Higher Education Academy), Fellow (2022-),
  • British Society for Cell Biology, Member (2009-),