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Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes

Authors: Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A.

Journal: European Journal of Obstetrics and Gynecology and Reproductive Biology

Volume: 274

Pages: 229-237

eISSN: 1872-7654

ISSN: 0301-2115

DOI: 10.1016/j.ejogrb.2022.06.001

Abstract:

Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite instability and genomic instability syndromes, due to the inability to repair newly replicated DNA. This article reviews the literature to date to elucidate the contribution of microsatellite instability to genomic instability syndromes and infertility. The key findings presented reveal microsatellite instability is poorly researched in genomic instability syndromes and infertility.

https://eprints.bournemouth.ac.uk/37076/

Source: Scopus

Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes.

Authors: Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A.

Journal: Eur J Obstet Gynecol Reprod Biol

Volume: 274

Pages: 229-237

eISSN: 1872-7654

DOI: 10.1016/j.ejogrb.2022.06.001

Abstract:

Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite instability and genomic instability syndromes, due to the inability to repair newly replicated DNA. This article reviews the literature to date to elucidate the contribution of microsatellite instability to genomic instability syndromes and infertility. The key findings presented reveal microsatellite instability is poorly researched in genomic instability syndromes and infertility.

https://eprints.bournemouth.ac.uk/37076/

Source: PubMed

Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes

Authors: Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A.

Journal: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY

Volume: 274

Pages: 229-237

eISSN: 1872-7654

ISSN: 0301-2115

DOI: 10.1016/j.ejogrb.2022.06.001

https://eprints.bournemouth.ac.uk/37076/

Source: Web of Science (Lite)

Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes.

Authors: Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A.

Journal: European journal of obstetrics, gynecology, and reproductive biology

Volume: 274

Pages: 229-237

eISSN: 1872-7654

ISSN: 0301-2115

DOI: 10.1016/j.ejogrb.2022.06.001

Abstract:

Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite instability and genomic instability syndromes, due to the inability to repair newly replicated DNA. This article reviews the literature to date to elucidate the contribution of microsatellite instability to genomic instability syndromes and infertility. The key findings presented reveal microsatellite instability is poorly researched in genomic instability syndromes and infertility.

https://eprints.bournemouth.ac.uk/37076/

Source: Europe PubMed Central

Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes.

Authors: Wieland, J., Buchan, S., Sen Gupta, S. and Mantzouratou, A.

Journal: European Journal of Obstetrics and Gynecology and Reproductive Biology

Volume: 274

Issue: July

Pages: 229-237

ISSN: 0301-2115

Abstract:

Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite instability and genomic instability syndromes, due to the inability to repair newly replicated DNA. This article reviews the literature to date to elucidate the contribution of microsatellite instability to genomic instability syndromes and infertility. The key findings presented reveal microsatellite instability is poorly researched in genomic instability syndromes and infertility.

https://eprints.bournemouth.ac.uk/37076/

Source: BURO EPrints