Modeling and Simulation of Growth in Diastolic Heart Failure

Authors: Namashiri, P., Allahverdizadeh, A. and Dadash Zadeh, B.

Journal: Journal of Applied and Computational Sciences in Mechanics

Volume: 35

Issue: 3

DOI: 10.22067/JACSM.2023.81490.1173


Heart failure is one of the cardiovascular diseases that causes changes in the structure and function of the heart and reduces the output of the heart. This disease can be divided into two categories: diastolic and systolic heart failure. In diastolic heart failure, the thickness of the ventricular walls increased and is associated with concentric hypertrophy. Heart failure is medically understandable, but in practice it is significantly sensitive to the type of loading of the myocardium and its microstructure, and this has made it difficult to predict the disease. In this study, concentric hypertrophy is assumed to be caused by pressure overload, as a result of which, the stress of the ventricular walls increases and causes an increase in the number of sarcomeres parallel to the previous sarcomeres, and as a result, causes a relative increase in the transverse area of the cardiomyocytes. Continuum equations of concentric hypertrophy by using an idealized biventricular geometry and defining the microstructure using a mathematical method have been implemented in COMSOL Multiphysics software, the approach presented for implementing the equations is completely new and has fundamental advantages over the implementation of the previous approach in this software. The results of the simulation of diastolic heart failure showed that the thickness of the ventricular walls increases due to pressure overload and the volume of the ventricular chambers decreases. The mentioned results are consistent with the clinical observations of the disease and shows that computational modeling can be used as a powerful tool to increase specialist’s knowledge of diseases that have a high mortality rate.

Source: Manual