Stability of new psychoactive substances in crude wastewater
Authors: Davies, B., Paul, R., Osselton, D. and Woolley, T.
Journal: Forensic Science, Medicine, and Pathology
eISSN: 1556-2891
ISSN: 1547-769X
DOI: 10.1007/s12024-024-00860-1
Abstract:Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration into society. The challenge extends beyond merely detecting and measuring NPS using analytical tools; it also encompasses the complexities arising from the formation and presence of metabolites and degradation products. This study utilises liquid chromatography time-of-flight mass spectrometry to investigate the stability of new psychoactive substances in wastewater. Seven NPS compounds including 25C-NBOMe, 5F-APINACA 4-hydroxyphenyl, AB-PINACA, APINACA 4-hydroxyphenyl, fentanyl, norfentanyl and MDPV, along with their corresponding internal standard, were examined. Reference material for each NPS compound was introduced into a wastewater sample from a Wessex water treatment plant. The sample was then exposed to four different environments: room temperature, refrigerator temperature, acidification to pH 2, and the introduction of sodium metabisulfite. The findings highlight the critical dependence of storage conditions on target analytes, emphasizing the paramount importance of the time elapsed between collection and analysis for NPS wastewater analysis. Notably, synthetic cannabinoids exhibit limited stability in wastewater whereas cathinone-like substances demonstrate greater stability. Furthermore, metabolites prove to be more stable in wastewater than the parent drug, suggesting that focusing on metabolite detection may be more favourable for future analysis.
https://eprints.bournemouth.ac.uk/40172/
Source: Scopus
Stability of new psychoactive substances in crude wastewater.
Authors: Davies, B., Paul, R., Osselton, D. and Woolley, T.
Journal: Forensic Sci Med Pathol
eISSN: 1556-2891
DOI: 10.1007/s12024-024-00860-1
Abstract:Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration into society. The challenge extends beyond merely detecting and measuring NPS using analytical tools; it also encompasses the complexities arising from the formation and presence of metabolites and degradation products. This study utilises liquid chromatography time-of-flight mass spectrometry to investigate the stability of new psychoactive substances in wastewater. Seven NPS compounds including 25C-NBOMe, 5F-APINACA 4-hydroxyphenyl, AB-PINACA, APINACA 4-hydroxyphenyl, fentanyl, norfentanyl and MDPV, along with their corresponding internal standard, were examined. Reference material for each NPS compound was introduced into a wastewater sample from a Wessex water treatment plant. The sample was then exposed to four different environments: room temperature, refrigerator temperature, acidification to pH 2, and the introduction of sodium metabisulfite. The findings highlight the critical dependence of storage conditions on target analytes, emphasizing the paramount importance of the time elapsed between collection and analysis for NPS wastewater analysis. Notably, synthetic cannabinoids exhibit limited stability in wastewater whereas cathinone-like substances demonstrate greater stability. Furthermore, metabolites prove to be more stable in wastewater than the parent drug, suggesting that focusing on metabolite detection may be more favourable for future analysis.
https://eprints.bournemouth.ac.uk/40172/
Source: PubMed
Stability of new psychoactive substances in crude wastewater
Authors: Davies, B., Paul, R., Osselton, D. and Woolley, T.
Journal: FORENSIC SCIENCE MEDICINE AND PATHOLOGY
eISSN: 1556-2891
ISSN: 1547-769X
DOI: 10.1007/s12024-024-00860-1
https://eprints.bournemouth.ac.uk/40172/
Source: Web of Science (Lite)
Stability of new psychoactive substances in crude wastewater
Authors: Davies, B., Paul, R., Osselton, D. and Wooley, T.
Journal: Forensic Science Medicine and Pathology
Publisher: Springer Nature
ISSN: 1547-769X
https://eprints.bournemouth.ac.uk/40172/
Source: Manual
Stability of new psychoactive substances in crude wastewater.
Authors: Davies, B., Paul, R., Osselton, D. and Woolley, T.
Journal: Forensic science, medicine, and pathology
eISSN: 1556-2891
ISSN: 1547-769X
DOI: 10.1007/s12024-024-00860-1
Abstract:Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration into society. The challenge extends beyond merely detecting and measuring NPS using analytical tools; it also encompasses the complexities arising from the formation and presence of metabolites and degradation products. This study utilises liquid chromatography time-of-flight mass spectrometry to investigate the stability of new psychoactive substances in wastewater. Seven NPS compounds including 25C-NBOMe, 5F-APINACA 4-hydroxyphenyl, AB-PINACA, APINACA 4-hydroxyphenyl, fentanyl, norfentanyl and MDPV, along with their corresponding internal standard, were examined. Reference material for each NPS compound was introduced into a wastewater sample from a Wessex water treatment plant. The sample was then exposed to four different environments: room temperature, refrigerator temperature, acidification to pH 2, and the introduction of sodium metabisulfite. The findings highlight the critical dependence of storage conditions on target analytes, emphasizing the paramount importance of the time elapsed between collection and analysis for NPS wastewater analysis. Notably, synthetic cannabinoids exhibit limited stability in wastewater whereas cathinone-like substances demonstrate greater stability. Furthermore, metabolites prove to be more stable in wastewater than the parent drug, suggesting that focusing on metabolite detection may be more favourable for future analysis.
https://eprints.bournemouth.ac.uk/40172/
Source: Europe PubMed Central
Stability of new psychoactive substances in crude wastewater
Authors: Davies, B., Paul, R., Osselton, D. and Wooley, T.
Journal: Forensic Science Medicine and Pathology
Publisher: Springer Nature
ISSN: 1547-769X
Abstract:Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration into society. The challenge extends beyond merely detecting and measuring NPS using analytical tools; it also encompasses the complexities arising from the formation and presence of metabolites and degradation products. This study utilises liquid chromatography time-of-flight mass spectrometry to investigate the stability of new psychoactive substances in wastewater. Seven NPS compounds including 25C-NBOMe, 5F-APINACA 4-hydroxyphenyl, AB-PINACA, APINACA 4-hydroxyphenyl, fentanyl, norfentanyl and MDPV, along with their corresponding internal standard, were examined. Reference material for each NPS compound was introduced into a wastewater sample from a Wessex water treatment plant. The sample was then exposed to four different environments: room temperature, refrigerator temperature, acidification to pH 2, and the introduction of sodium metabisulfite. The findings highlight the critical dependence of storage conditions on target analytes, emphasizing the paramount importance of the time elapsed between collection and analysis for NPS wastewater analysis. Notably, synthetic cannabinoids exhibit limited stability in wastewater whereas cathinone-like substances demonstrate greater stability. Furthermore, metabolites prove to be more stable in wastewater than the parent drug, suggesting that focusing on metabolite detection may be more favourable for future analysis.
https://eprints.bournemouth.ac.uk/40172/
Source: BURO EPrints