Stimulating whole saliva affects the response of antimicrobial proteins to exercise
Authors: Allgrove, J.E., Oliveira, M. and Gleeson, M.
Journal: Scandinavian Journal of Medicine and Science in Sports
Volume: 24
Issue: 4
Pages: 649-655
eISSN: 1600-0838
ISSN: 0905-7188
DOI: 10.1111/sms.12056
Abstract:This study investigated the salivary secretion rates of antimicrobial proteins in response to prolonged, exhaustive exercise in both stimulated (STIM) and unstimulated (UNSTIM) saliva flow sample methods. Twenty-four trained men cycled for 2.5h at 60% V ̇ O 2 m a x and then to exhaustion at 75% V ̇ O 2 m a x Timed collections of whole saliva were made before exercise, mid-exercise, at the end of the moderate exercise bout and post-exhaustive exercise. After each UNSTIM collection, a STIM sample was collected following chewing flavored gum for 1min. Saliva was analysed for lysozyme, α-amylase and salivary immunoglobulin A (s-IgA), and secretion rates were calculated. Saliva flow was 156% higher in STIM compared with UNSTIM (P<0.001) and decreased with exercise in STIM only (P<0.001). Exercise increased lysozyme and α-amylase levels and secretion rates were 144% higher and 152% higher in STIM compared with UNSTIM for lysozyme and α-amylase, respectively (all P<0.001). S-IgA concentration (P<0.05) and secretion rate (P<0.001) increased with exercise but were both lower in STIM compared with UNSTIM (P<0.001). In conclusion, a STIM saliva flow collection during exercise by chewing flavored gum increased the quantity of saliva and the secretion of lysozyme and α-amylase, but had a limited impact on the secretion of s-IgA. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Source: Scopus
