Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias
Authors: Paul, R., Tsanaclis, L., Murray, C., Boroujerdi, R., Facer, L. and Corbin, A.
Journal: Alcohol and Alcoholism
Volume: 54
Issue: 4
Pages: 402-407
eISSN: 1464-3502
ISSN: 0735-0414
DOI: 10.1093/alcalc/agz015
Abstract:Aims: This work aimed to assess the performance of hair and fingernail ethyl glucuronide (EtG) measurement for use as a biomarker of alcohol consumption in persons with known drinking history across a range of drinking behaviours. Methods: EtG concentrations were assessed from the hair and fingernails of 50 study participants. Alcohol consumption of the previous 90 days was assessed by participant interview using the alcohol timeline follow-back method. EtG concentration was determined using LC-MS-MS using a method which was validated and accredited to ISO/IEC 17025 standards. Results: There was significant correlation between alcohol consumption and EtG concentrations found in hair and fingernail samples across the study group (n = 50). From participants testing positive for EtG (male n = 14, female n = 13) no significant difference was found between male and female EtG levels in either hair or fingernails. Across all participants there was no significant difference in hair or fingernail EtG concentration between male (n = 23) and females (n = 27). Conclusions: Our results support the use of EtG to indicate alcohol consumption over the previous 90 days, or ~3 months as is the normal practice in hair analysis. The results confirm that fingernails can be a useful alternative matrix where hair samples are not available.
Source: Scopus
Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias.
Authors: Paul, R., Tsanaclis, L., Murray, C., Boroujerdi, R., Facer, L. and Corbin, A.
Journal: Alcohol Alcohol
Volume: 54
Issue: 4
Pages: 402-407
eISSN: 1464-3502
DOI: 10.1093/alcalc/agz015
Abstract:AIMS: This work aimed to assess the performance of hair and fingernail ethyl glucuronide (EtG) measurement for use as a biomarker of alcohol consumption in persons with known drinking history across a range of drinking behaviours. METHODS: EtG concentrations were assessed from the hair and fingernails of 50 study participants. Alcohol consumption of the previous 90 days was assessed by participant interview using the alcohol timeline follow-back method. EtG concentration was determined using LC-MS-MS using a method which was validated and accredited to ISO/IEC 17025 standards. RESULTS: There was significant correlation between alcohol consumption and EtG concentrations found in hair and fingernail samples across the study group (n = 50). From participants testing positive for EtG (male n = 14, female n = 13) no significant difference was found between male and female EtG levels in either hair or fingernails. Across all participants there was no significant difference in hair or fingernail EtG concentration between male (n = 23) and females (n = 27). CONCLUSIONS: Our results support the use of EtG to indicate alcohol consumption over the previous 90 days, or ~3 months as is the normal practice in hair analysis. The results confirm that fingernails can be a useful alternative matrix where hair samples are not available.
Source: PubMed
Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias
Authors: Paul, R., Tsanaclis, L., Murray, C., Boroujerdi, R., Facer, L. and Corbin, A.
Journal: ALCOHOL AND ALCOHOLISM
Volume: 54
Issue: 4
Pages: 402-407
eISSN: 1464-3502
ISSN: 0735-0414
DOI: 10.1093/alcalc/agz015
Source: Web of Science (Lite)
Ethyl Glucuronide as a Long-Term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias
Authors: Paul, R., Tsanaclis, L., Murray, C., Boroujerdi, R., Facer, L. and Corbin, A.
Journal: Alcohol and Alcoholism
Publisher: OUP
ISSN: 0735-0414
DOI: 10.1093/alcalc/agz015
Source: Manual
Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias.
Authors: Paul, R., Tsanaclis, L., Murray, C., Boroujerdi, R., Facer, L. and Corbin, A.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire)
Volume: 54
Issue: 4
Pages: 402-407
eISSN: 1464-3502
ISSN: 0735-0414
DOI: 10.1093/alcalc/agz015
Abstract:Aims
This work aimed to assess the performance of hair and fingernail ethyl glucuronide (EtG) measurement for use as a biomarker of alcohol consumption in persons with known drinking history across a range of drinking behaviours.Methods
EtG concentrations were assessed from the hair and fingernails of 50 study participants. Alcohol consumption of the previous 90 days was assessed by participant interview using the alcohol timeline follow-back method. EtG concentration was determined using LC-MS-MS using a method which was validated and accredited to ISO/IEC 17025 standards.Results
There was significant correlation between alcohol consumption and EtG concentrations found in hair and fingernail samples across the study group (n = 50). From participants testing positive for EtG (male n = 14, female n = 13) no significant difference was found between male and female EtG levels in either hair or fingernails. Across all participants there was no significant difference in hair or fingernail EtG concentration between male (n = 23) and females (n = 27).Conclusions
Our results support the use of EtG to indicate alcohol consumption over the previous 90 days, or ~3 months as is the normal practice in hair analysis. The results confirm that fingernails can be a useful alternative matrix where hair samples are not available.Source: Europe PubMed Central