The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis

Authors: Fairbairn, P., Dyall, S.C. and Tsofliou, F.

Journal: British Journal of Nutrition

eISSN: 1475-2662

ISSN: 0007-1145

DOI: 10.1017/S0007114522001283

Abstract:

There is now evidence to suggest that there may be an interaction between B vitamins and omega-3 polyunsaturated fatty acids (PUFAs), with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of omega-3 PUFAs and B vitamins can prevent cognitive decline in older adults. Randomised control trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of omega-3 PUFAs and B vitamins alone, or in combination with other nutrients. Trials that provided omega-3 PUFAs alone and also measured B vitamin status or provided B vitamin supplementation alone and measured omega-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus, and MEDLINE. A total of 14 papers were included in the analysis (n=4913; age: 60-70 y; follow up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both omega-3 PUFAs and B vitamins alongside other nutrients, versus placebo on global cognition assessed using composite scores from a neuropsychological test battery (G=0.23, P=0.002), global cognition using single measures of cognition (G=0.28, P=0.004) and episodic memory (G=0.32, P=0.001). The results indicate that providing a combination of omega-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults versus a placebo, the potential for an interaction between these key nutrients should be considered in future experimental work.

http://eprints.bournemouth.ac.uk/36903/

Source: Scopus

The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis.

Authors: Fairbairn, P., Dyall, S.C. and Tsofliou, F.

Journal: Br J Nutr

Pages: 1-42

eISSN: 1475-2662

DOI: 10.1017/S0007114522001283

Abstract:

There is now evidence to suggest that there may be an interaction between B vitamins and omega-3 polyunsaturated fatty acids (PUFAs), with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of omega-3 PUFAs and B vitamins can prevent cognitive decline in older adults. Randomised control trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of omega-3 PUFAs and B vitamins alone, or in combination with other nutrients. Trials that provided omega-3 PUFAs alone and also measured B vitamin status or provided B vitamin supplementation alone and measured omega-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus, and MEDLINE. A total of 14 papers were included in the analysis (n=4913; age: 60-70 y; follow up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both omega-3 PUFAs and B vitamins alongside other nutrients, versus placebo on global cognition assessed using composite scores from a neuropsychological test battery (G=0.23, P=0.002), global cognition using single measures of cognition (G=0.28, P=0.004) and episodic memory (G=0.32, P=0.001). The results indicate that providing a combination of omega-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults versus a placebo, the potential for an interaction between these key nutrients should be considered in future experimental work.

http://eprints.bournemouth.ac.uk/36903/

Source: PubMed

The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis

Authors: Fairbairn, P., Dyall, S.C. and Tsofliou, F.

Journal: BRITISH JOURNAL OF NUTRITION

eISSN: 1475-2662

ISSN: 0007-1145

DOI: 10.1017/S0007114522001283

http://eprints.bournemouth.ac.uk/36903/

Source: Web of Science (Lite)

The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis

Authors: Fairbairn, P., Dyall, S. and Tsofliou, F.

Journal: The British Journal of Nutrition: an international journal of nutritional science

Publisher: Cambridge University Press

ISSN: 0007-1145

http://eprints.bournemouth.ac.uk/36903/

Source: Manual

The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis.

Authors: Fairbairn, P., Dyall, S.C. and Tsofliou, F.

Journal: The British journal of nutrition

Pages: 1-42

eISSN: 1475-2662

ISSN: 0007-1145

DOI: 10.1017/s0007114522001283

Abstract:

There is now evidence to suggest that there may be an interaction between B vitamins and omega-3 polyunsaturated fatty acids (PUFAs), with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of omega-3 PUFAs and B vitamins can prevent cognitive decline in older adults. Randomised control trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of omega-3 PUFAs and B vitamins alone, or in combination with other nutrients. Trials that provided omega-3 PUFAs alone and also measured B vitamin status or provided B vitamin supplementation alone and measured omega-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus, and MEDLINE. A total of 14 papers were included in the analysis (n=4913; age: 60-70 y; follow up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both omega-3 PUFAs and B vitamins alongside other nutrients, versus placebo on global cognition assessed using composite scores from a neuropsychological test battery (G=0.23, P=0.002), global cognition using single measures of cognition (G=0.28, P=0.004) and episodic memory (G=0.32, P=0.001). The results indicate that providing a combination of omega-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults versus a placebo, the potential for an interaction between these key nutrients should be considered in future experimental work.

http://eprints.bournemouth.ac.uk/36903/

Source: Europe PubMed Central

The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis

Authors: Fairbairn, P., Dyall, S. and Tsofliou, F.

Journal: The British Journal of Nutrition: an international journal of nutritional science

Publisher: Cambridge University Press

ISSN: 0007-1145

Abstract:

There is now evidence to suggest that there may be an interaction between B vitamins and omega-3 polyunsaturated fatty acids (PUFAs), with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of omega-3 PUFAs and B vitamins can prevent cognitive decline in older adults. Randomised control trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of omega-3 PUFAs and B vitamins alone, or in combination with other nutrients. Trials that provided omega-3 PUFAs alone and also measured B vitamin status or provided B vitamin supplementation alone and measured omega-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus, and MEDLINE. A total of 14 papers were included in the analysis (n=4913; age: 60-70 y; follow up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both omega-3 PUFAs and B vitamins alongside other nutrients, versus placebo on global cognition assessed using composite scores from a neuropsychological test battery (G=0.23, P=0.002), global cognition using single measures of cognition (G=0.28, P=0.004) and episodic memory (G=0.32, P=0.001). The results indicate that providing a combination of omega-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults versus a placebo, the potential for an interaction between these key nutrients should be considered in future experimental work.

http://eprints.bournemouth.ac.uk/36903/

Source: BURO EPrints